Etiologic factors in the pathogenesis of liver tumors associated with oral contraceptives

Within the last several years, previously rare liver tumors have been seen in young women using oral contraceptive steroids. The Registry for Liver Tumors Associated with Oral Contraceptives at the University of California, Irvine, has clearly identified 27 cases. The recent literature contains 44 c...

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Bibliographic Details
Published inAmerican journal of obstetrics and gynecology Vol. 127; no. 1; p. 61
Main Authors Nissen, E D, Kent, D R, Nissen, S E
Format Journal Article
LanguageEnglish
Published United States 01.01.1977
Subjects
Adenoma
Adult
California
Carcinoma, Hepatocellular - chemically induced
Contraceptives, Oral - administration & dosage
Contraceptives, Oral - adverse effects
Estradiol Congeners - administration & dosage
Estradiol Congeners - adverse effects
Female
Hamartoma - chemically induced
Humans
Hyperplasia - chemically induced
Liver
Liver Neoplasms - chemically induced
Progesterone Congeners - administration & dosage
Progesterone Congeners - adverse effects
Registries
California
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Summary:Within the last several years, previously rare liver tumors have been seen in young women using oral contraceptive steroids. The Registry for Liver Tumors Associated with Oral Contraceptives at the University of California, Irvine, has clearly identified 27 cases. The recent literature contains 44 case reports. Common to these 71 cases has been a histopathologic diagnosis of focal nodular hyperplasia, adenoma, hamartoma, and hepatoma. Significant statistical etiologic factors include prolonged uninterrupted usage of oral contraceptive steroids. Eight deaths and liver rupture in 18 patients attest to the seriousness of this new potentially lethal adverse phenomenon.
ISSN:0002-9378
DOI:10.1016/0002-9378(77)90315-5