Clinical Characteristics, Imaging Findings and Surgical Outcomes of Chiari Malformation Type I in Pediatric and Adult Patients

• Published in: Current medical science Vol. 38; no. 2; pp. 289 - 295
• Main Authors: Lei, Zhuo-wei, Wu, Shi-qiang, Zhang, Zhuo, Han, Yang, Wang, Jun-wen, Li, Feng, Shu, Kai
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.04.2018; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China%Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China
• Subjects: Medicine; Medicine & Public Health; clinical manifestations; Chiari malformation type I; surgical outcome; adult patients; pediatric patients; Chiari malformation type
• ISSN: 2096-5230; 2523-899X; 1672-0733; 2523-899X
• DOI: 10.1007/s11596-018-1877-2

Summary A growing number of children and adolescents are being diagnosed as Chiari malformation type I (CM-I) for behavioral disorders, developmental delay, seizures, or abnormal orpharyngeal function. The aim of this study was to compare the clinical characteristics, imaging findings and surgical outcomes of CM-I in pediatric and adult patients. Between January 2014 and June 2017, 84 patients with CM-I underwent surgical treatment in our department. We divided the patients into two groups: pediatric group ( n =11, age <18 years) and adult group ( n =73, age ≥18 years). Data on clinical characteristics, imaging findings, surgical outcomes, and prognosis were retrospectively reviewed and compared between these two groups. For clinical presentation, scoliosis (36.4%) and developmental delay (36.4%) were more common in pediatric patients, whereas, sensory disturbance (58.9%) and motor weakness (41.1%) were more common in adult patients. Imaging findings showed that the incidence of hydrocephalus and craniovertebral junctional abnormalities was significantly higher in pediatric group than in adult group ( P <0.05). Compared to adult group, pediatric group showed a better improvement or resolution of syrinx and tonsillar herniation after surgical treatments ( P <0.05). The total Chicago Chiari Outcome Scale (CCOS) score in pediatric patients at the last followup was significantly higher than that in adult patients ( P =0.002). In conclusion, the clinical characteristics and imaging findings appeared to be different in pediatric and adult patients with CM-I. The surgical outcomes of pediatric patients were shown to be significantly better than those of adult patients.