Human umbilical cord blood (HUCB) cells for central nervous system repair

Cellular therapy is a compelling and potential treatment for certain neurological and neurodegenerative diseases as well as a viable treatment for acute injury to the spinal cord and brain. The hematopoietic system offers alternative sources for stem cells compared to those of fetal or embryonic ori...

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Published inNeurotoxicity research Vol. 5; no. 5; pp. 355 - 368
Main Authors Newman, Mary B, Davis, Cyndy D, Kuzmin-Nichols, Nicole, Sanberg, Paul R
Format Journal Article
LanguageEnglish
Published United States 2003
Subjects
Animals
Central Nervous System Diseases - therapy
Cord Blood Stem Cell Transplantation
Humans
Infant, Newborn
Neurons - physiology
Phenotype
Rats
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Summary:Cellular therapy is a compelling and potential treatment for certain neurological and neurodegenerative diseases as well as a viable treatment for acute injury to the spinal cord and brain. The hematopoietic system offers alternative sources for stem cells compared to those of fetal or embryonic origin. Bone marrow stromal and umbilical cord cells have been used in pre-clinical models of brain injury, directed to differentiate into neural phenotypes, and have been related to functional recovery after engraftment in central nervous system (CNS) injury models. This paper reviews the advantages, utilization and progress of human umbilical cord blood (HUCB) cells in the neural cell transplantation and repair field.
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ISSN:1029-8428
1476-3524
DOI:10.1007/bf03033155