Synthesis, magnetic properties, surface modification and cytotoxicity evaluation of Y3Fe5-xAlxO12 (0≤x≤2) garnet submicron particles for biomedical applications

• Published in: Journal of magnetism and magnetic materials Vol. 234; no. 3; pp. 409 - 418
• Main Authors: GRASSET, Fabien, MORNET, Stéphane, DEMOURGUES, Alain, PORTIER, Josik, BONNET, Jacques, VEKRIS, Antoine, DUGUET, Etienne
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Science 01.09.2001; Elsevier
• Subjects: Biological and medical sciences; Chemical Sciences; Condensed matter: electronic structure, electrical, magnetic, and optical properties; Cross-disciplinary physics: materials science; rheology; Exact sciences and technology; Fine-particle systems; Inorganic chemistry; Magnetic properties and materials; Material chemistry; Materials science; Medical sciences; Nanoscale materials and structures: fabrication and characterization; Physics; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Small particles and nanoscale materials; Studies of specific magnetic materials; Technology. Biomaterials. Equipments. Material. Instrumentation; Inorganic compounds; Transition element compounds; Cytotoxicity; Experimental study; Magnetic particles; Garnets; YIG; Biomaterial; Iron oxides; Chemical synthesis; Quaternary compounds; Citrate process; TEM; Yttrium oxides; Aluminium oxides; Magnetic properties
• ISSN: 0304-8853; 1873-4766
• DOI: 10.1016/s0304-8853(01)00386-9

Yttrium aluminum iron garnet Y3Fe5−xAlxO12 compounds were produced by the citrate gel process by varying the aluminum content x from 0 to 2. Particles with an average size of about 100 nm and a specific surface area ranging from 6 to 28 m2/g were obtained. Curie temperatures (TC) were determined from the temperature dependence of the field-cooled magnetization (FCM) and the remnant magnetization (REM) and range from –40°C to 280°C. According to the magnetic moment variation, the aluminum cation seems to replace the iron cation in the tetrahedral site for compounds with x<0.7. 3-Aminopropyltrimethoxysilane (γ-APS) was grafted onto the particles surface and its presence confirmed by infra-red spectroscopy. Cytotoxicity assays were carried out during a period of 13 days using human microglia and rat glioblastoma cell lines. The presence of the amine-functionalized particles did not affect the cell viability or the culture growth rate. Finally, amine-functionalized particles were successfully labeled with covalently linked fluorescing molecules.