Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations
Introduction Apolipoprotein E (APOE) is considered the major susceptibility gene for developing Alzheimer's disease. However, the strength of this risk factor is not well established across diverse Hispanic populations. Methods We investigated the associations among APOE genotype, dementia prev...
Saved in:
Published in | Alzheimer's & dementia Vol. 19; no. 2; pp. 602 - 610 |
---|---|
Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.02.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Introduction
Apolipoprotein E (APOE) is considered the major susceptibility gene for developing Alzheimer's disease. However, the strength of this risk factor is not well established across diverse Hispanic populations.
Methods
We investigated the associations among APOE genotype, dementia prevalence, and memory performance (immediate and delayed recall scores) in Caribbean Hispanics (CH), African Americans (AA), Hispanic Americans (HA) and non‐Hispanic White Americans (NHW). Multivariable logistic regressions and negative binomial regressions were used to examine these associations by subsample.
Results
Our final dataset included 13,516 participants (5198 men, 8318 women) across all subsamples, with a mean age of 74.8 years. Prevalence of APOE ε4 allele was similar in CHs, HAs, and NHWs (21.8%–25.4%), but was substantially higher in AAs (33.6%; P < 0.001). APOE ε4 carriers had higher dementia prevalence across all groups.
Discussion
APOE ε4 was similarly associated with increased relative risk of dementia and lower memory performance in all subsamples. |
---|---|
Bibliography: | Jorge J Llibre Guerra and Jing Li are joint first authors. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 AUTHOR CONTRIBUTIONS Jorge Llibre-Guerra and Jing Li had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Jorge J. Llibre-Guerra, Juan J. Llibre Rodriguez, William H. Dow. Acquisition, analysis, or interpretation of data: All authors. Drafting of the manuscript: Jorge J. Llibre-Guerra, Jing Li. Critical revision of the manuscript for important intellectual content: All authors. Statistical analysis: Jing Li, Yuting Qian. Obtained funding: William H. Dow. Project administration: Mao-Mei Liu. Study supervision: Juan de Jesús Llibre Rodriguez, Ivonne Z. Jiménez Velázquez, Daisy Acosta, Aquiles Salas, William H. Dow. |
ISSN: | 1552-5260 1552-5279 |
DOI: | 10.1002/alz.12699 |