An accurate, high-throughput method for genotyping the −373AnTn polymorphism in the interleukin-6 promoter
Summary Interleukin‐6 (IL‐6) is a pro‐inflammatory cytokine implicated in inflammatory diseases. The four promoter polymorphisms (−174G/C, −373AnTn, −572G/C, −597G/A) have been shown to function as a haplotype in determining IL‐6 gene transcription. Using a capillary‐based electrophoresis system, hi...
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Published in | International Journal of Immunogenetics Vol. 33; no. 2; pp. 65 - 67 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.04.2006
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Subjects | |
Online Access | Get full text |
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Summary: | Summary
Interleukin‐6 (IL‐6) is a pro‐inflammatory cytokine implicated in inflammatory diseases. The four promoter polymorphisms (−174G/C, −373AnTn, −572G/C, −597G/A) have been shown to function as a haplotype in determining IL‐6 gene transcription. Using a capillary‐based electrophoresis system, high‐throughput genotyping for the −373AnTn polymorphism was achieved, thus facilitating IL‐6 promoter haplotype determination. |
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Bibliography: | ark:/67375/WNG-S4QRCT3N-X istex:98DCCA942F9E9018A48179D574B89840F1865EEA ArticleID:IJI569 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1744-3121 1744-313X 1365-2370 |
DOI: | 10.1111/j.1744-313X.2006.00569.x |