Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice

The effects of fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work. Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and...

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Published inFrontiers in immunology Vol. 13; p. 916618
Main Authors Tang, Yunping, Pu, Qiuyan, Zhao, Qiaoling, Zhou, Yafeng, Jiang, Xiaoxia, Han, Tao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 19.05.2022
Subjects
Animals
cyclophosphamide
Cyclophosphamide - pharmacology
fucoidan
Gastrointestinal Microbiome
gut microbiota
Immunity
Immunology
immunomodulatory
immunosuppression
Laminaria
Mice
Polysaccharides
cyclophosphamide
immunosuppression
fucoidan
gut microbiota
immunomodulatory
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Summary:The effects of fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work. Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum. Moreover, LF could regulate intestinal flora composition, increasing the abundance of and , and inhibiting , , , , and . These results were positively correlated with immune characteristics. Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders.
Bibliography:Edited by: Bin Du, Hebei Normal University of Science and Technology, China
Reviewed by: Fei Peng, Hebei Normal University of Science and Technology, China; Xiaoting Fu, Ocean University of China, China
This article was submitted to Nutritional Immunology, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.916618