Report of three cases of circulating heparin‐like anticoagulants

• Published in: American journal of hematology Vol. 67; no. 4; pp. 256 - 258
• Main Authors: Llamas, Pilar, Outeiriño, Julio, Espinoza, José, Santos, Ana B., Román, Alejandro, Tomás, José F.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.08.2001; Wiley-Liss
• Subjects: Aged; Anticoagulants - blood; Biological and medical sciences; bleeding; circulating heparin‐like anticoagulant; Hematologic and hematopoietic diseases; Hematologic Neoplasms - blood; Hematologic Neoplasms - complications; hematological malignancies; Hemorrhage - etiology; Heparin - blood; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Thrombin Time; Case study; Human; Symptomatology; Circulating anticoagulant; Pathophysiology; Complication; Male; Anticoagulant; Malignant hemopathy; Heparin; Hemorrhage
• ISSN: 0361-8609; 1096-8652
• DOI: 10.1002/ajh.1126

Clinically significant endogenous circulating heparin‐like anticoagulant activity has been associated with hematological malignancies, liver damage, and other pathological conditions. The source of high plasma concentrations of endogenous heparin‐like anticoagulants is poorly understood. We report three cases of circulating heparin‐like anticoagulants in three patients with hematological malignancies: CLL, multiple myeloma, and T‐prolymphocytic leukemia. The severity of bleeding in our patients ranged from severe epistaxis and deep‐site hematoma to bleeding of biopsy site and occasional ecchymosis. Am. J. Hematol. 67:256–258, 2001. © 2001 Wiley‐Liss, Inc.