Leukocytic fibrinolysis in myelomonocytic leukemia

A case of myelomonocytic leukemia is described in which an increase in primary fibrinolytic activity produced a severe hemorrhagic diathesis. The leukemic cells were demonstrated to be the source of the fibrinolytic activity. Utilizing a fibrin coated slide technique, the intact leukemic cells were...

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Bibliographic Details
Published inCancer Vol. 39; no. 4; pp. 1618 - 1624
Main Authors Talarico, Lilia, Weintraub, Lewis R.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.04.1977
Subjects
Animals
Blood Coagulation
Cats
Fibrinolysis
Hemorrhage - complications
Humans
Leukemia, Myeloid - blood
Leukemia, Myeloid - complications
Leukemia, Myeloid - physiopathology
Leukocytes - enzymology
Leukocytes - physiology
Male
Peptide Hydrolases - metabolism
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Summary:A case of myelomonocytic leukemia is described in which an increase in primary fibrinolytic activity produced a severe hemorrhagic diathesis. The leukemic cells were demonstrated to be the source of the fibrinolytic activity. Utilizing a fibrin coated slide technique, the intact leukemic cells were shown to release their fibrinolytic activity and to induce local lysis. Intact leukocytes from normal subjects and other patients with acute leukemia of varied cell types were unable to release fibrinolytic activity although in some of the leukemic preparations, increased fibrinolytic activity was demonstrated after in vitor disruption of the cells.
Bibliography:Associate Professor of Medicine.
Assistant Professor of Medicine.
ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197704)39:4<1618::AID-CNCR2820390436>3.0.CO;2-Q