Leukocytic fibrinolysis in myelomonocytic leukemia
A case of myelomonocytic leukemia is described in which an increase in primary fibrinolytic activity produced a severe hemorrhagic diathesis. The leukemic cells were demonstrated to be the source of the fibrinolytic activity. Utilizing a fibrin coated slide technique, the intact leukemic cells were...
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Published in | Cancer Vol. 39; no. 4; pp. 1618 - 1624 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
New York
Wiley Subscription Services, Inc., A Wiley Company
01.04.1977
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Subjects | |
Online Access | Get full text |
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Summary: | A case of myelomonocytic leukemia is described in which an increase in primary fibrinolytic activity produced a severe hemorrhagic diathesis. The leukemic cells were demonstrated to be the source of the fibrinolytic activity. Utilizing a fibrin coated slide technique, the intact leukemic cells were shown to release their fibrinolytic activity and to induce local lysis. Intact leukocytes from normal subjects and other patients with acute leukemia of varied cell types were unable to release fibrinolytic activity although in some of the leukemic preparations, increased fibrinolytic activity was demonstrated after in vitor disruption of the cells. |
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Bibliography: | Associate Professor of Medicine. Assistant Professor of Medicine. ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
ISSN: | 0008-543X 1097-0142 |
DOI: | 10.1002/1097-0142(197704)39:4<1618::AID-CNCR2820390436>3.0.CO;2-Q |