new cyclitol derivative influences inositol metabolism in Neurospora crassa

Cyclitol derivatives have been synthesized and screened for growth inhibitory effect upon prokaryotic and eukaryotic organisms. One derivative, (2S,3R,5R)-3-azido-2-benzoyloxy-5-hydroxycyclohexanone, was studied in detail: it has no effect upon bacteria, but it is inhibitory to Neurospora crassa. In...

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Published inFEMS microbiology letters Vol. 82; no. 1; pp. 15 - 18
Main Authors Szabo, G, Schablik, M, Kiss, A, Koncz, C, Bognar, R, Pelyvas, I, Sztaricskai, F
Format Journal Article
LanguageEnglish
Published England 15.07.1991
Subjects
Cell Division - drug effects
cyclitols
Cyclohexanones - pharmacology
enzyme activity
growth
inhibition
Inositol - metabolism
inositol phosphates
ligases
lithium
Lithium - pharmacology
mechanism of action
metabolic inhibitors
metabolism
myo-inositol
myo-inositol-1-phosphate synthase
Myo-Inositol-1-Phosphate Synthase - metabolism
Neurospora crassa
Neurospora crassa - drug effects
Neurospora crassa - growth & development
Neurospora crassa - metabolism
Phosphoric Monoester Hydrolases - antagonists & inhibitors
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Summary:Cyclitol derivatives have been synthesized and screened for growth inhibitory effect upon prokaryotic and eukaryotic organisms. One derivative, (2S,3R,5R)-3-azido-2-benzoyloxy-5-hydroxycyclohexanone, was studied in detail: it has no effect upon bacteria, but it is inhibitory to Neurospora crassa. In Neurospora crassa it increased the amount of myo-inositol-1-phosphate synthase and inhibited the activity of myo-inositol-monophophatase. The enhanced synthesis of myo-inositol-1-phosphate synthase was the consequence of lowering the intracellular inositol concentration. Li+ treatment of Neurospora crassa has effects similar to those of P.I.-658.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1991.tb04832.x