The Application Value of the Renal Region of Interest Corrected by Computed Tomography in Single-Kidney Glomerular Filtration Rate for the Evaluation of Patients With Moderate or Severe Hydronephrosis

• Published in: Frontiers in physiology Vol. 13; p. 861895
• Main Authors: Yin, Haixia, Liang, Wenli, Zhao, Deshan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.05.2022
• Subjects: computed tomography; dynamic renal scintigraphy; glomerular filtration rate; hydronephrosis; Physiology; renal region of interest; computed tomography; renal region of interest; glomerular filtration rate; hydronephrosis; dynamic renal scintigraphy
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2022.861895

This study aimed to investigate the application value of the renal region of interest (ROI) corrected by computed tomography (CT) in single-kidney glomerular filtration rate (GFR) in patients with hydronephrosis. A total of 46 patients with hydronephrosis were divided into four groups based on their degree of unilateral hydronephrosis: a normal group (left kidney and right kidney) and three abnormal groups (mild, moderate, and severe hydronephrosis). GFR was measured using the two-sample method (tGFR). The single-kidney GFR of each patient was derived from differential renal function values in dynamic renal imaging multiplied by GFR. The single-kidney GFRs, including GFR from the Gates method (gGFR ) and CT area-corrected GFR (aGFR ), were compared with tGFR . A paired-sample -test and Pearson's test were used for data analysis. < 0.05 was considered statistically significant. There were no significant differences between aGFR and tGFR in patients in the normal, mild hydronephrosis, and moderate hydronephrosis groups ( = -0.604∼1.982, all > 0.05), but there was a significant difference between them in the severe hydronephrosis group ( = 2.302, < 0.05). There were no significant differences between gGFR and tGFR in the normal and mild hydronephrosis groups ( = 0.194∼0.962, all > 0.05), but there was a significant difference between them in the moderate and severe hydronephrosis groups ( = 3.321, 3.494, < 0.05). Both gGFR and aGFR were correlated with tGFR , with aGFR being more strongly correlated ( = 0.890, < 0.001). In patients with moderate hydronephrosis, aGFR is more strongly correlated with tGFR than gGFR . However, in patients with severe hydronephrosis and accompanying renal morphological changes, the aGFR measured by the renal ROI area-correction method using CT has higher accuracy and better clinical application value than the conventional gGFR .