From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus

In the endemic variants of pemphigus foliaceus (PF), in Brazil and Tunisia, patients generate pathogenic IgG4 anti-desmoglein 1 autoantibodies. Additionally, these patients possess antibodies against salivary proteins from sand flies that react with Dsg1, which may lead to skin disease in susceptibl...

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Bibliographic Details
Published inFrontiers in immunology Vol. 13; p. 907424
Main Authors Li, Ning, Aoki, Valeria, Liu, Zhi, Prisayanh, Phillip, Valenzuela, Jesus G, Diaz, Luis A
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 27.05.2022
Subjects
Animals
autoantibodies
Autoimmune Diseases
Desmoglein 1
fogo selvagem (FS)
Humans
Immunology
Insect Bites and Stings - epidemiology
Pemphigus - epidemiology
Psychodidae
sandflies
Tunisian pemphigus foliaceus
Tunisian pemphigus foliaceus
desmoglein 1
sandflies
fogo selvagem (FS)
autoantibodies
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Summary:In the endemic variants of pemphigus foliaceus (PF), in Brazil and Tunisia, patients generate pathogenic IgG4 anti-desmoglein 1 autoantibodies. Additionally, these patients possess antibodies against salivary proteins from sand flies that react with Dsg1, which may lead to skin disease in susceptible individuals living in endemic areas. This minireview focuses on recent studies highlighting the possible role of salivary proteins from ( ) in EPF from Brazil and ( ) in EPF from Tunisia. We will briefly discuss the potential mechanisms of molecular mimicry and epitope spreading in the initiation and development of endemic PF (EPF) in Brazil and Tunisia.
Bibliography:Edited by: Giovanni Di Zenzo, Istituto Dermopatico dell’Immacolata (IDI) (IRCCS), Italy
Reviewed by: Franziska Vielmuth, Ludwig Maximilian University of Munich, Germany; Maryam Daneshpazhooh, Tehran University of Medical Sciences, Iran
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.907424