Melatonin response to atrial natriuretic peptide administration in healthy volunteers

Recent observations have demonstrated that the pineal hormone melatonin (MLT) plays a role in the neuroendocrine control of the cardiovascular system. On the other hand, it has been observed that the cardiac hormone alpha-atrial natriuretic peptide (ANP) may regulate the neuroendocrine functions. Th...

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Bibliographic Details
Published inJournal of cardiovascular pharmacology Vol. 16; no. 5; p. 850
Main Authors Lissoni, P, Pelizzoni, F, Grugni, G, Guzzaloni, G, Mauri, O, Archili, C, Galli, M A, Morabito, F
Format Journal Article
LanguageEnglish
Published United States 01.11.1990
Subjects
Adolescent
Adult
Atrial Natriuretic Factor - pharmacology
Blood Pressure - drug effects
Female
Heart Rate - drug effects
Humans
Male
Melatonin - blood
Pineal Gland - drug effects
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Summary:Recent observations have demonstrated that the pineal hormone melatonin (MLT) plays a role in the neuroendocrine control of the cardiovascular system. On the other hand, it has been observed that the cardiac hormone alpha-atrial natriuretic peptide (ANP) may regulate the neuroendocrine functions. The present study was carried out to investigate the possible relationship between cardiac and pineal endocrine functions. Six healthy volunteers were treated on two different occasions with placebo or ANP at a dose of 0.1 mg i.v. as a bolus. An increase of greater than 100% in MLT serum levels was seen in 2/6 subjects. These preliminary results would suggest that ANP may play a role in the regulation of MLT secretion. Further studies will be needed to define better the cardiac-pineal interactions.
ISSN:0160-2446
DOI:10.1097/00005344-199011000-00024