Interventional oncology: new options for interstitial treatments and intravascular approaches Targeting tumor metabolism via a loco-regional approach: a new therapy against liver cancer
Recent research in tumor metabolism has uncovered cancer-cell-specific pathways that cancer cells depend on for energy production. 3-Bromopyruvate (3-BrPA), a specific alkylating agent and potent ATP inhibitor, has been shown both in vitro and in vivo to disrupt some of these cancer-specific metabol...
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Published in | Journal of hepato-biliary-pancreatic sciences Vol. 17; no. 4; pp. 405 - 406 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Japan
Springer Japan
01.07.2010
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Subjects | |
Online Access | Get full text |
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Summary: | Recent research in tumor metabolism has uncovered cancer-cell-specific pathways that cancer cells depend on for energy production. 3-Bromopyruvate (3-BrPA), a specific alkylating agent and potent ATP inhibitor, has been shown both in vitro and in vivo to disrupt some of these cancer-specific metabolic pathways, thereby leading to the demise of the cancer cells through apoptosis. 3-BrPA has been successfully tested in animal models of liver cancer. For optimal results, 3-BrPA can be delivered intra-arterially, with minimal toxicity to the surrounding hepatic parenchyma. In the era of development of drugs with lower toxicity for the treatment of liver cancer, inhibition of cancer metabolism with 3-BrPA appears to be a very attractive potent novel therapeutic option. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1868-6974 1868-6982 |
DOI: | 10.1007/s00534-009-0236-x |