X-Linked Hypophosphatemia: Does Targeted Therapy Modify Dental Impairment?

X-linked hypophosphatemia is a rare, hereditary disorder that significant influences teeth and alveolar bone. The first clinical sign leading to the diagnosis of X-linked hypophosphatemia is often dental impairment with dental abscesses and dentin mineralization defects. Genetic analysis helped find...

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Bibliographic Details
Published inJournal of clinical medicine Vol. 12; no. 24; p. 7546
Main Authors Abdullah, Anusha, Wuersching, Sabina Noreen, Kollmuss, Maximilian, Poxleitner, Philipp, Dewenter, Ina, Brandenburg, Leonard Simon, Steybe, David, Fegg, Florian Nepomuk, Smolka, Wenko, Otto, Sven, Obermeier, Katharina Theresa
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.12.2023
Subjects
Abscess
Abscesses
Care and treatment
Clinical medicine
Defects
Dental enamel
Dentin
Diagnosis
Disease
Drug resistance
Drug targeting
Evaluation
Genetic aspects
Genotype & phenotype
Hypophosphatemia
Methods
Mutation
Pathophysiology
Phosphatase
Phosphates
Physiological aspects
Rickets
Risk factors
Teeth
Vitamin D
Vitamin deficiency
X chromosomes
Germany
Burosumab
X-linked hypophosphatemia
vitamin-D-resistant rickets
dental abscesses
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Summary:X-linked hypophosphatemia is a rare, hereditary disorder that significant influences teeth and alveolar bone. The first clinical sign leading to the diagnosis of X-linked hypophosphatemia is often dental impairment with dental abscesses and dentin mineralization defects. Genetic analysis helped find the responsible gene and therefore opened up new ways of therapeutically managing X-linked hypophosphatemia. The human monoclonal antibody Burosumab represents a milestone in the targeted therapy of this hereditary disease by directly addressing its pathophysiology. Targeted therapy has been shown to improve skeletal impairment, pain, and phosphate metabolism. However, the influence of this new therapy on dental impairment has only been addressed in a few recent studies with varying results. Therefore, in this review, we aim to summarize the dental phenotype and analyze the different treatment modalities with a focus on dental impairment.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12247546