Biodegradable Chitosan-g-Poly(methacrylamide) Microspheres for Controlled Release of Hypertensive Drug

• Published in: Journal of polymers and the environment Vol. 21; no. 4; pp. 1128 - 1134
• Main Authors: Swamy, Bala Yerri, Prasad, Chavidi Venkata, Prabhakar, M. N., Chowdoji Rao, Kashay, Subha, M. C. S., Chung, Ildoo
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.12.2013; Springer; Springer Nature B.V
• Subjects: Applied sciences; Biodegradation; Biological and medical sciences; Calorimetry; Chemical properties; Chemistry; Chemistry and Materials Science; Drug therapy; Environmental Chemistry; Environmental Engineering/Biotechnology; Exact sciences and technology; Fourier transforms; General pharmacology; Hypertension; Industrial Chemistry/Chemical Engineering; Infrared spectroscopy; Materials Science; Medical sciences; Natural polymers; Original Paper; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Polymer Sciences; Starch and polysaccharides; Microspheres; Chitosan; Graft copolymer; Enalapril maleate; Poly(methacrylamide); Water oil emulsion; Methacrylamide copolymer; Control release polymer; Crosslinking; Drug carrier; Glutaral; Experimental study; Property processing relationship; Grafting; In vitro; Chitosan derivatives; Enalapril; Preparation; Oside polymer; Antihypertensive agent; Microgel; Microencapsulation; Kinetics; Release
• ISSN: 1566-2543; 1572-8919; 1572-8900
• DOI: 10.1007/s10924-012-0554-y

Chitosan-g-poly(methacrylamide) (CS-g-PMAAm) was synthesized by redox polymerization. The synthesized graft copolymers were used to prepare microspheres (MS) by water/oil (W/O) emulsion technique and cross-linked with glutaraldehyde (GA). Developed microspheres were encapsulated using enalapril maleate (ENAM) as a model drug (hypertension) and characterized by fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy. The physico-chemical properties of the microspheres were studied by calculating drug entrapment efficiency, and drug release kinetics. % of encapsulation efficiency (% EE) increased with increase in drug loading and methacrylamide (MAAm) content. The minimum % EE (65.2 ± 1.6) was observed in case of microsphere containing 40 % MAAm, 5 % ENAM and 10 mL glutaraldehyde. The release profiles indicate that formulation containing highest (10 mL) crosslinking agent microspheres has the slow release.