Circadian coupling of mitochondria in a deep-diving mammal

• Published in: Journal of experimental biology Vol. 227; no. 7
• Main Authors: Ciccone, Chiara, Kante, Fayiri, Folkow, Lars P, Hazlerigg, David G, West, Alexander C, Wood, Shona H
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 01.04.2024
• Subjects: Animals; ARNTL Transcription Factors - metabolism; Brain - metabolism; Caniformia; Hypoxia - metabolism; Mammals - metabolism; Mitochondria - metabolism; Seals, Earless - physiology; Biological clock; Mitochondrial respiration; Hypoxia; Arctic; Hooded seal; Pinniped

Regulation of mitochondrial oxidative phosphorylation is essential to match energy supply to changing cellular energy demands, and to cope with periods of hypoxia. Recent work implicates the circadian molecular clock in control of mitochondrial function and hypoxia sensing. Because diving mammals ex...