Effect of Aqueous Extracts of Quercus resinosa on the Mechanical Behavior of Bigels

• Published in: Scientia pharmaceutica Vol. 90; no. 4; p. 73
• Main Authors: Gallegos-Infante, José Alberto, Galindo-Galindo, María del Pilar, Moreno-Jiménez, Martha Rocío, Rocha-Guzmán, Nuria Elizabeth, González-Laredo, Rubén Francisco
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.01.2022
• Subjects: Acne; bigels; drug delivery; Hydrogels; Mechanical properties; Microorganisms; Polyphenols; Rheology; Shear stress; Viscoelasticity; Viscosity; United States > US
• ISSN: 2218-0532; 0036-8709; 2218-0532
• DOI: 10.3390/scipharm90040073

Quercus resinosa leaves are rich in polyphenol compounds, however, they are unstable to several chemical and physical factors that limit their activity. Several methods have been developed to solve such problems, among which bigels can be mentioned and obtained using hydrogels and oleogels. The mechanical characterization of this type of materials is by using rheological methods. Although the use of these methods is well documented, the Carreau-Yasuda model has been little used to evaluate the effect of polyphenols on the mechanical behavior of bigels. Therefore, bigels were obtained from hydrogels (guar gum/xanthan gum, 0.5/0.5% w/v) and oleogels (sesame oil/sorbitan monostearate 10% w/w). Micrographs, linear viscoelasticity range, frequency sweep, and single shear tests were performed. The data were analyzed using ANOVA and Tukey test (p < 0.05); micrographs showed linear relationship between polyphenols concentration and droplet size. Liquid fraction of bigels showed a pseudoplastic behavior, while the parameters of Carreau-Yasuda model showed that the highest value of the complex viscosity at zero shear was at the lowest concentration of extract; the relaxation time presented the lowest value at higher concentrations of extracts. These results indicate that the presence of polyphenols modifyes the mechanical behavior of bigels.