Is there a role for Tc-99m (V) DMSA scintigraphy in ischemic colitis?

To evaluate the role of pentavalent Tc-99m dimercaptosuccinic acid [Tc-99m (V) DMSA] in the diagnosis of ischemic colitis. Fourteen patients with endoscopically and histologically confirmed ischemic colitis were included in the study. Tc-99m (V) DMSA scintigraphy was performed within 2 d after colon...

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Published inWorld journal of gastroenterology : WJG Vol. 14; no. 35; pp. 5432 - 5435
Main Authors Stathaki, Maria I, Koutroubakis, Ioannis E, Koukouraki, Sophia I, Kouroumalis, Elias A, Karkavitsas, Nikolaos S
Format Journal Article
LanguageEnglish
Published United States The WJG Press and Baishideng 21.09.2008
Subjects
Aged
Colitis, Ischemic - diagnosis
Colitis, Ischemic - diagnostic imaging
Colonoscopy
False Negative Reactions
Female
Humans
Male
Radionuclide Imaging
Radiopharmaceuticals
Rapid Communication
Sensitivity and Specificity
Technetium Tc 99m Dimercaptosuccinic Acid
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Summary:To evaluate the role of pentavalent Tc-99m dimercaptosuccinic acid [Tc-99m (V) DMSA] in the diagnosis of ischemic colitis. Fourteen patients with endoscopically and histologically confirmed ischemic colitis were included in the study. Tc-99m (V) DMSA scintigraphy was performed within 2 d after colonoscopy. Images were considered positive when an area of increased activity was observed in the region of interest and negative when no abnormal tracer uptake was detected. In 3 out of the 14 patients, Tc-99m (V) DMSA images showed moderate activity in the bowel. The scintigraphic results corresponded with the endoscopic findings. In the other 11 patients, no abnormal tracer uptake was detected in the abdomen. Besides the limited number of patients, Tc-99m (V) DMSA could not be considered as a useful imaging modality for the evaluation of ischemic colitis.
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Author contributions: Stathaki MI, Koukouraki SI, Karkavitsas NS performed and evaluated the scintigraphic images; Koutroubakis IE, Kouroumalis EA collected all clinical data; Stathaki MI, Koutroubakis IE analyzed the data and wrote the paper.
Correspondence to: Ioannis E Koutroubakis, MD, PhD, Assistant Professor of Medicine, University Hospital Heraklion, Department of Gastroenterology, PO Box 1352, Heraklion 71110, Crete, Greece. ktjohn@her.forthnet.gr
Telephone: +30-28-10392253 Fax: +30-28-10542085
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.14.5432