An Automatic Lab-on-Disc System for Blood Typing

A blood-typing assay is a critical test to ensure the serological compatibility of a donor and an intended recipient prior to a blood transfusion. This article presents a lab-on-disc blood-typing system to conduct a total of eight assays for a patient, including forward-typing tests, reverse-typing...

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Bibliographic Details
Published inSLAS technology Vol. 23; no. 2; pp. 172 - 178
Main Authors Chang, Yaw-Jen, Fan, Yi-Hua, Chen, Shia-Chung, Lee, Kuan-Hua, Lou, Liao-Yong
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.04.2018
Subjects
Automation, Laboratory - instrumentation
Automation, Laboratory - methods
Blood Grouping and Crossmatching - instrumentation
Blood Grouping and Crossmatching - methods
Humans
Lab-On-A-Chip Devices
blood typing
RBC agglutination
lab-on-disc
manual polybrene (MP) method
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Summary:A blood-typing assay is a critical test to ensure the serological compatibility of a donor and an intended recipient prior to a blood transfusion. This article presents a lab-on-disc blood-typing system to conduct a total of eight assays for a patient, including forward-typing tests, reverse-typing tests, and irregular-antibody tests. These assays are carried out in a microfluidic disc simultaneously. A blood-typing apparatus was designed to automatically manipulate the disc. The blood type can be determined by integrating the results of red blood cell (RBC) agglutination in the microchannels. The experimental results of our current 40 blood samples show that the results agree with those examined in the hospital. The accuracy reaches 97.5%.
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ISSN:2472-6303
2472-6311
DOI:10.1177/2472630317744732