Renal tubular dysgenesis with atypical histology and in-utero exposure to naproxen sodium

• Published in: Annals of tropical paediatrics Vol. 26; no. 3; pp. 241 - 245
• Main Authors: KOKLU, Esad, GURGOZE, Metin, AKGUN, Hulya, OZTURK, Mehmet Adnan, HAKAN POYRAZOGLU, M
• Format: Journal Article
• Language: English
• Published: Leeds Maney 01.09.2006; Taylor & Francis Ltd
• Subjects: Adult; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Anuria - congenital; Anuria - etiology; Biological and medical sciences; Fatal Outcome; Female; Humans; Infant, Newborn; Kidney Tubules, Proximal - abnormalities; Kidney Tubules, Proximal - pathology; Kidneys; Malformations of the urinary system; Maternal-Fetal Exchange; Medical sciences; Naproxen - adverse effects; Nephrology. Urinary tract diseases; Pregnancy; Prenatal Exposure Delayed Effects; Asia; Turkey; Human; Kidney disease; Renal tubular dysgenesis; Prostaglandin-endoperoxide synthase; Pediatrics; Dysgenesia; Urinary system disease; Enzyme; Enzyme inhibitor; Exposure; Histology; Congenital disease; In utero; Non steroidal antiinflammatory agent; Case study; Renal tubule; Analgesic; Newborn; Malformation; Naproxen; Antipyretic; Arylpropionic acid derivatives; Tropical medicine; Oxidoreductases
• ISSN: 0272-4936; 2046-9047; 1465-3281; 2046-9055
• DOI: 10.1179/146532806X120345

Renal tubular dysgenesis (RTD), a rare, lethal, autosomal recessive disorder, is characterised by short and poorly differentiated proximal convoluted tubules associated with oligohydramnios, Potter sequence and neonatal death from respiratory failure. We report an unusual case of neonatal anuria owing to RTD with normally formed lungs, in-utero exposure to naproxen sodium and atypical histology in that the glomeruli were not as crowded as usually seen in RTD. When there is anuria in an infant following birth in the context of a normal renal ultrasound and an absence of objective evidence of perinatal hypoxia, RTD should be considered.