Induction of hepatic microsomal enzymes by diuron, phenobenzuron, and metabolites in rats

Microsomal liver enzymes are induced in rats which are fed a diet containing 1000 ppm of phenobenzuron, a phenylurea herbicide, for 7 days: All parameters measured are about 50% higher than control values. This increase is lower after 14 feeding days. Diuron and 3,4-dichloroaniline have a similar, a...

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Bibliographic Details
Published inEcotoxicology and environmental safety Vol. 1; no. 2; p. 197
Main Authors Corthay, J, Medilanski, P, Benakis, A
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.1977
Subjects
Animals
Benzoates - pharmacology
Cytochrome P-450 Enzyme System - metabolism
Diuron - pharmacology
Enzyme Induction - drug effects
Growth - drug effects
Herbicides - pharmacology
Hippurates - pharmacology
Male
Methylurea Compounds - pharmacology
Microsomes, Liver - drug effects
Microsomes, Liver - enzymology
Phenylurea Compounds
Proteins - metabolism
Rats
Time Factors
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Summary:Microsomal liver enzymes are induced in rats which are fed a diet containing 1000 ppm of phenobenzuron, a phenylurea herbicide, for 7 days: All parameters measured are about 50% higher than control values. This increase is lower after 14 feeding days. Diuron and 3,4-dichloroaniline have a similar, although lower, effect than phenobenzuron. Two other metabolites have no action on microsomal enzymes. The transitory and weak inducing effect of these phenylureas is interesting when compared to other organochlorine pesticides.
Bibliography:H
H00
ISSN:0147-6513
1090-2414
DOI:10.1016/0147-6513(77)90035-5