Imaging correlates of serum enzyme-linked immunoelectrotransfer blot (EITB) positivity in patients with parenchymal neurocysticercosis: results from 521 patients

• Published in: Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 116; no. 2; pp. 117 - 123
• Main Authors: Vasudevan, Prabhakaran, Moorthy, Ranjith K, Rebekah, Grace, Jackson, Ellen, Pamela, Betcy Evangeline, Thamizhmaran, Subashini, Manoj, Josephin, Thanigachalam, Anupriya, Drevets, Douglas, Carabin, Hélène, Rajshekhar, Vedantam
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.02.2022
• Subjects: Animals; Antibodies, Helminth; Cysticercus; Granuloma; Humans; Multivariate Analysis; Neurocysticercosis - complications; Neurocysticercosis - diagnostic imaging; Original; antibodies; cysticercus; edema; immunoblotting; neurocysticercosis
• ISSN: 0035-9203; 1878-3503
• DOI: 10.1093/trstmh/trab091

Abstract Background The presence of perilesional edema among patients with parenchymal neurocysticercosis (pNCC) of various lesion subtypes has not been correlated with results of serum enzyme-linked immunotransfer blot (EITB) for cysticercal antibodies. Methods In total, 521 patients with pNCC were classified into solitary cysticercus granuloma (SCG), multiple lesions, at least one of which was an enhancing granuloma (GMNCC), solitary calcified cysticercal lesion (SCC) and multiple calcified cysticercal lesions (CMNCC). The proportion of EITB positivity among each lesion subtype and its association with perilesional edema were determined. Results There were significantly higher positive EITB results in patients with GMNCC (90/111, 81.1%) compared with other lesion types. Perilesional edema was associated with positive EITB in patients with CMNCC. On univariate analysis, perilesional edema and GMNCC were associated with EITB positivity. On multivariate analysis, only GMNCC (OR 7.5; 95% CI 3.5 to 16.2) was significantly associated with EITB positivity. Conclusions In patients with pNCC, the presence of perilesional edema is associated with a higher probability of a positive EITB result in patients with CMNCC, suggesting a synchronicity in the mechanisms associated with formation of perilesional edema and the antibody response in this subtype. In patients with enhancing granulomas, edema is not an independent predictor of a positive EITB, suggesting that the enhancement itself is associated with a strong antibody response.