Three New Dexpanthenol-Containing Face Creams: Performance and Acceptability after Single and Repeated Applications in Subjects of Different Ethnicity with Dry and Sensitive Skin

Three novel face creams containing dexpanthenol with different lipid contents were developed for dry skin sufferers: a day face cream (DFC), a day face cream with sun protection (DFC-SPF), and a night face cream (NFC). Three identically designed studies (N = 42–44 each) were conducted with healthy a...

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Published inCosmetics (Basel) Vol. 8; no. 4; p. 93
Main Authors Barrionuevo-Gonzalez, Ana, Trapp, Sonja, de Salvo, Raffaella, Reitmann, Marina, Cassar, Eva, Rharbaoui, Siham, Reber, Florence, Stettler, Hans
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.12.2021
Subjects
Ceramide
Cholesterol
Cultural differences
dexpanthenol
dry skin
Ethnicity
Face
face cream
Females
Hydration
Lipids
Minority & ethnic groups
moisturization
Physiology
Questionnaires
Skin
Stratum corneum
study
Ultraviolet radiation
White people
Switzerland
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Summary:Three novel face creams containing dexpanthenol with different lipid contents were developed for dry skin sufferers: a day face cream (DFC), a day face cream with sun protection (DFC-SPF), and a night face cream (NFC). Three identically designed studies (N = 42–44 each) were conducted with healthy adults of three ethnicities (African, Asian, Caucasian) with dry/sensitive skin. Effects on stratum corneum (SC) hydration, SC lipid content, and skin elasticity were quantified by established noninvasive methods during the 4-week studies. After single and repeated once-daily applications of the face creams, facial hydration significantly increased from baseline. On day 28, the mean increments in skin hydration amounted to 27%, 26%, and 27% (p < 0.0001 each) for DFC, DFC-SPF, and NFC, respectively. Favorable effects of DFC, DFC-SPF, and NFC on facial moisturization were observed in all three ethnic groups. The enhancements in SC hydration were not paralleled by improvements in skin elasticity parameters but lipid analyses showed significant increases in SC cholesterol, SC free fatty acid, and/or SC ceramide levels. All three face creams were well tolerated and achieved a high product satisfaction and acceptability by study participants. Our findings support the once-daily use of the face creams in adults of different ethnicities with dry and sensitive skin.
ISSN:2079-9284
2079-9284
DOI:10.3390/cosmetics8040093