Nondisjunction — A View from Ringside

Chromosome nondisjunction lands a heavy blow on the chin of humanity. The improper segregation of chromosomes during meiosis leads to chromosomally unbalanced eggs or sperm. If these gametes participate in fertilization, the outcome is an aneuploid embryo, with either trisomy (one chromosome too man...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 351; no. 19; pp. 1931 - 1934
Main Authors Lamb, Neil E, Hassold, Terry J
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 04.11.2004
Subjects
Abortion, Spontaneous - genetics
Aneuploidy
Cell division
Chromosomes
Embryo Loss - genetics
Embryos
Female
Genetics
Humans
Male
Maternal Age
Meiosis
Models, Genetic
Nondisjunction, Genetic
Pregnancy
Recombination, Genetic
Spermatocytes
Trisomy
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Summary:Chromosome nondisjunction lands a heavy blow on the chin of humanity. The improper segregation of chromosomes during meiosis leads to chromosomally unbalanced eggs or sperm. If these gametes participate in fertilization, the outcome is an aneuploid embryo, with either trisomy (one chromosome too many) or monosomy (one chromosome too few). Since most such embryos are inviable, one might expect that these errors would be extremely rare. This is true for most organisms, but our own species is a notable exception: aneuploidy is identified in at least 5 percent of all clinically recognized pregnancies, making it the leading known cause of . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMp048118