Synthesis and physicochemical evaluation of a new carrier based on an interpolyelectrolyte complex formed by Eudragit® EPO and Carbomer 940

The formation of interpolyelectrolyte complexes (IPEC) between Eudragit® EPO (EPO) and Carbomer 940 (C940) was investigated with a view to their use in peroral controlled-release drug delivery systems. The structure of the synthesized products was investigated using FTIR spectroscopy and MT—DSC meth...

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Published inPharmaceutical chemistry journal Vol. 44; no. 5; pp. 271 - 273
Main Authors Mustafin, R. I, Kabanova, T. V, Zhdanova, E. R, Bukhovets, A. V, Garipova, V. R, Nasibullin, Sh. F, Kemenova, V. A
Format Journal Article
LanguageEnglish
Published Boston Boston : Springer US 01.10.2010
Springer US
Springer
Subjects
Acrylic acid
Carbomer 940
Drug delivery systems
Drugs
Erythropoietin
Eudragit® EPO
interpolyelectrolyte complexes
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
physicochemical properties
Vehicles
interpolyelectrolyte complexes
Carbomer 940
physicochemical properties
EPO
Eudragit
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Summary:The formation of interpolyelectrolyte complexes (IPEC) between Eudragit® EPO (EPO) and Carbomer 940 (C940) was investigated with a view to their use in peroral controlled-release drug delivery systems. The structure of the synthesized products was investigated using FTIR spectroscopy and MT—DSC methods, which indicated that the synthesized product can be considered to be an IPEC stabilized by a cooperative system of ionic bonds. Based on results of capillary viscosimetry and elemental analysis, the IPEC prepared at pH 4.0 has a characteristic composition with a C940:EPO mole ratio of 1.75:1.
Bibliography:http://dx.doi.org/10.1007/s11094-010-0447-0
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-010-0447-0