Tissue residues and withdrawal time of moxidectin treatment of swine by topical pour-on application

• Published in: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment Vol. 38; no. 4; pp. 602 - 608
• Main Authors: Jicheng, Qiu, Hongzhi, Xiao, Pan, Sun, Yuying, Cao, Qinyao, Wu, Ximo, Zhang, Lu, Zhang, Xiaohui, Gong, Xingyuan, Cao, Feifei, Sun
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.04.2021; Taylor & Francis Ltd
• Subjects: Antiparasitic agents; Depletion; Dosage; Food safety; High-performance liquid chromatography; Kidneys; Liquid chromatography; Moxidectin; Muscles; Parasites; Residues; Swine; Tissues; withdrawal time; swine; withdrawal time; Moxidectin
• ISSN: 1944-0049; 1944-0057
• DOI: 10.1080/19440049.2021.1877833

Moxidectin (MXD), an antiparasitic drug, is effective for a variety of external and internal parasites in companion and farm animals. This study aimed to calculate the withdrawal period by investigating the residue depletion of MXD in swine edible tissues after pouring at the dosage of 2.5 mg/kg B.W. The concentrations of MXD in swine edible tissues were determined by a modified preparation procedure based on HPLC-FLD. The method was validated giving LOD and LOQ of 0.5 μg/kg and 1 μg/kg respectively with measured recoveries ranging from 62.9%-89.2% at three different concentrations and a precision (RSD) of less or equal to 15.7%. The muscle, liver, kidney and fat tissues were collected at 0.5, 5, 10, 20, 25 d after administration. The results showed that fat was the target tissue with the highest concentration for MXD. The withdrawal period was 26 days for the MRL of 500 μg/kg in fat. The results provide fundamental information to ensure food safety and establishment of a rational medication regimen.