Antimalarial activity of Sida acuta Burm. f. (Malvaceae) and Pterocarpus erinaceus Poir. (Fabaceae)

Among strategies to combat malaria, the search for new antimalarial drugs appears to be a priority. Sheering for new antimalarial activities, four plants of the traditional medicine of Burkina Faso: Combretum micranthum, Khaya senegalensis, Pterocarpus erinaceus and Sida acuta, were tested in vitro...

Full description

Saved in:
Bibliographic Details
Published inJournal of ethnopharmacology Vol. 89; no. 2; pp. 291 - 294
Main Authors Karou, Damintoti, Dicko, Mamoudou H., Sanon, Souleymane, Simpore, Jacques, Traore, Alfred S.
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 01.12.2003
Elsevier
Subjects
Alkaloids
Animals
Antimalarials - pharmacology
Biological and medical sciences
Cells, Cultured
Combretum - chemistry
Erythrocytes - drug effects
General pharmacology
Humans
In Vitro Techniques
Malaria
Malvaceae - chemistry
Medical sciences
Medicine, African Traditional
Meliaceae - chemistry
Parasitic Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - pharmacology
Plant Structures - chemistry
Plasmodium falciparum
Plasmodium falciparum - drug effects
Pterocarpus - chemistry
Pterocarpus erinaceus
Sida acuta
Burkina Faso
Africa
Sida acuta
Plasmodium falciparum
Alkaloids
Pterocarpus erinaceus
Malaria
Malvaceae
Human
Protozoa
Antimalarial
Apicomplexa
Pharmacognosy
In vitro
Plasmodium falciparam
Biological activity
Medicinal plant
Leguminosae
Folk medicine
Dicotyledones
Angiospermae
Plant origin
Parasiticide
Spermatophyta
Clinical isolate
Online AccessGet full text

Cover

More Information
Summary:Among strategies to combat malaria, the search for new antimalarial drugs appears to be a priority. Sheering for new antimalarial activities, four plants of the traditional medicine of Burkina Faso: Combretum micranthum, Khaya senegalensis, Pterocarpus erinaceus and Sida acuta, were tested in vitro on fresh clinical isolates of Plasmodium falciparum. The screening showed that Sida acuta has a significant activity (IC 50<5 μg/ml), and Pterocarpus erinaceus has a moderate activity (5 μg/ml<IC 50<50 μg/ml). Further chemical screening showed that the activity of the most active plant, Sida acuta, was related to its alkaloid contents.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2003.09.010