Insulin sensitivity affects corticolimbic brain responses to visual food cues in polycystic ovary syndrome patients

• Published in: Hormone molecular biology and clinical investigation Vol. 24; no. 2; pp. 101 - 115
• Main Authors: Alsaadi, Hanin M., Van Vugt, Dean A.
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.11.2015; Walter de Gruyter GmbH
• Subjects: Adolescent; Adult; Appetite Regulation; Body Mass Index; Cues; Down-Regulation; Female; Food; functional magnetic resonance imaging; Functional Neuroimaging; glucose challenge; Humans; Hyperglycemia; Insulin; Insulin Resistance; Limbic Lobe - metabolism; Magnetic Resonance Imaging; Neurons - metabolism; Obesity - complications; Overweight - complications; Photic Stimulation; Photography; Polycystic ovary syndrome; Polycystic Ovary Syndrome - blood; Polycystic Ovary Syndrome - complications; Polycystic Ovary Syndrome - metabolism; Young Adult
• ISSN: 1868-1883; 1868-1891
• DOI: 10.1515/hmbci-2015-0048

This study examined the effect of insulin sensitivity on the responsiveness of appetite regulatory brain regions to visual food cues. Nineteen participants diagnosed with polycystic ovary syndrome (PCOS) were divided into insulin-sensitive (n=8) and insulin-resistant (n=11) groups based on the homeostatic model assessment of insulin resistance (HOMA2-IR). Subjects underwent functional magnetic resonance imaging (fMRI) while viewing food pictures following water or dextrose consumption. The corticolimbic blood oxygen level dependent (BOLD) responses to high-calorie (HC) or low-calorie (LC) food pictures were compared within and between groups. BOLD responses to food pictures were reduced during a glucose challenge in numerous corticolimbic brain regions in insulin-sensitive but not insulin-resistant subjects. Furthermore, the degree of insulin resistance positively correlated with the corticolimbic BOLD response in the medial prefrontal cortex (mPFC), orbitofrontal cortex (OFC), anterior cingulate and ventral tegmental area (VTA) in response to HC pictures, and in the dorsolateral prefrontal cortex (DLPFC), mPFC, anterior cingulate, and insula in response to LC pictures following a glucose challenge. BOLD signal in the OFC, midbrain, hippocampus, and amygdala following a glucose challenge correlated with HOMA2-IR in response to HC-LC pictures. We conclude that the normal inhibition of corticolimbic brain responses to food pictures during a glucose challenge is compromised in insulin-resistant subjects. The increase in brain responsiveness to food pictures during postprandial hyperinsulinemia may lead to greater non-homeostatic eating and perpetuate obesity in insulin-resistant subjects.