Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility：A meta-analysis

• Published in: World journal of gastroenterology : WJG Vol. 17; no. 34; pp. 3941 - 3947
• Main Author: Wei, Yong-Gang
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 14.09.2011
• Subjects: Alleles; Asian Continental Ancestry Group - genetics; Brief; Carcinoma, Hepatocellular - genetics; Databases, Factual; Female; Genetic Predisposition to Disease; Humans; Interleukin-10 - genetics; Liver Neoplasms - genetics; Male; MEDLINE; Polymorphism, Genetic; Risk Factors; 固定效应模型; 国家知识基础设施; 基因多态性; 易感性; 白细胞介素10; 肝癌; 随机效应模型; Hepatocellular carcinoma; Interleukin-10; Gene polymorphism; Meta-analysis
• ISSN: 1007-9327; 2219-2840; 2219-2840
• DOI: 10.3748/wjg.v17.i34.3941

AIM： To assess the association between Interleu-kin-10 （IL-10） gene IL-10-1082 （G/A）, IL-10-592（C/A）, IL-10-819 （T/C） polymorphisms and hepatocellular carcinoma （HCC） susceptibility.METHODS： Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios （ORs） and 95% conf idence intervals （95% CIs） for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model （the Mantel-Haenszel method） and a random-effects model （the DerSimonian and Laird method） when appropriate. RESULTS： This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC （AA vs AG ＋ GG, OR = 1.11, 95% CI = 0.90-1.37）. When stratifying for ethnicity, the results were similar （Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60）. In the overall analysis, the IL-10 polymorphism at position -592 （C/A） was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592＊C allele had an increased risk of HCC （OR = 1.29, 95% CI = 1.12-1.49）. No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility （TT vs TC ＋ CC, OR = 1.02, 95% CI = 0.79-1.32）.CONCLUSION： This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC.