The impact of obesity on male fertility

Obesity in men of reproductive age is globally on the increase. There is clear evidence from epidemiological studies that obesity impacts negatively on male fertility; it is associated with hypogonadism, although it is less consistently linked to impaired spermatogenesis and tests of sperm function,...

Full description

Saved in:
Bibliographic Details
Published inHormones (Athens, Greece) Vol. 14; no. 4; pp. 563 - 568
Main Authors Chambers, Thomas J. G., Anderson, Richard A.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.10.2015
Subjects
Animals
DNA Damage
Endocrinology
Female
Fertility
Humans
Hypogonadism - etiology
Hypogonadism - pathology
Hypogonadism - physiopathology
Hypogonadism - prevention & control
Infertility, Male - etiology
Infertility, Male - pathology
Infertility, Male - physiopathology
Infertility, Male - prevention & control
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Obesity - complications
Obesity - pathology
Obesity - physiopathology
Obesity - therapy
Pregnancy
Prognosis
Review
Risk Assessment
Risk Factors
Spermatogenesis
Spermatozoa - pathology
Weight Loss
Fertility
Sperm
Infertility
Paternal
Metabolic syndrome
Hypogonadism
Overweight
Online AccessGet full text

Cover

Abstract Obesity in men of reproductive age is globally on the increase. There is clear evidence from epidemiological studies that obesity impacts negatively on male fertility; it is associated with hypogonadism, although it is less consistently linked to impaired spermatogenesis and tests of sperm function, including DNA fragmentation. Sperm from obese men used for in vitro fertilisation/intra cytoplasmic sperm injection is associated with a greater number of pregnancy losses and is less likely to result in live births. There are also increasing data from animal studies that paternal obesity may impact negatively on the reproductive and metabolic health of offspring and grand-offspring. It has been suggested that high-fat dietary exposures could affect the epigenetic content of sperm or the endocrine content of seminal fluid and thus impact early fetal development. Experimental and epidemiological data show that male fertility, and offspring health, can be improved by weight loss in obese and overweight males.
AbstractList Obesity in men of reproductive age is globally on the increase. There is clear evidence from epidemiological studies that obesity impacts negatively on male fertility; it is associated with hypogonadism, although it is less consistently linked to impaired spermatogenesis and tests of sperm function, including DNA fragmentation. Sperm from obese men used for in vitro fertilisation/intra cytoplasmic sperm injection is associated with a greater number of pregnancy losses and is less likely to result in live births. There are also increasing data from animal studies that paternal obesity may impact negatively on the reproductive and metabolic health of offspring and grand-offspring. It has been suggested that high-fat dietary exposures could affect the epigenetic content of sperm or the endocrine content of seminal fluid and thus impact early fetal development. Experimental and epidemiological data show that male fertility, and offspring health, can be improved by weight loss in obese and overweight males.
Author Anderson, Richard A.
Chambers, Thomas J. G.
Author_xml – sequence: 1
  givenname: Thomas J. G.
  surname: Chambers
  fullname: Chambers, Thomas J. G.
  organization: MRC Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh
– sequence: 2
  givenname: Richard A.
  surname: Anderson
  fullname: Anderson, Richard A.
  email: richard.anderson@ed.ac.uk
  organization: MRC Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26732149$$D View this record in MEDLINE/PubMed
BookMark eNp1kD1PwzAQhi1URD9gZkPZYEl7_ogdj6jiS6rEUmYrdc40VRIXOxn670lpYWM66e55X-meKRm1vkVCbinMqeAUFlsfmjkDYHMqGb0gE5YxSHPF6IhMKAWdctB6TKYx7gBkpnN6RcZMKs6o0BNyv95iUjX7wnaJd4nfYKy6Q-LbpClqTByGrqqHzTW5dEUd8eY8Z-Tj-Wm9fE1X7y9vy8dVarnSXSqZtqhBaSwdapZbDohFKcSGC8m5BidFVmrqnIRcOJQcqEJmsxw0FyXwGXk49e6D_-oxdqaposW6Llr0fTRUSSF1zhQf0MUJtcHHGNCZfaiaIhwMBfNjxxztmKMdc7QzJO7O5f2mwfKP_9UxAHAC4nBqPzGYne9DOzz8b-c32fVv6g
CitedBy_id crossref_primary_10_5812_ijem_101776
crossref_primary_10_37349_eff_2023_00014
crossref_primary_10_3390_metabo11120840
crossref_primary_10_3390_jcm9051400
crossref_primary_10_15280_jlm_2024_14_1_20
crossref_primary_10_31857_S0131164622600690
crossref_primary_10_3390_toxics10060295
crossref_primary_10_4236_ojog_2023_132023
crossref_primary_10_1111_and_14598
crossref_primary_10_3389_fendo_2022_839034
crossref_primary_10_3389_fendo_2021_622292
crossref_primary_10_3389_fendo_2023_1193150
crossref_primary_10_3389_fendo_2022_1021263
crossref_primary_10_3390_ijerph19031303
crossref_primary_10_1016_j_ygcen_2022_114104
crossref_primary_10_2174_1573399816666200819114032
crossref_primary_10_3389_fphys_2022_896735
crossref_primary_10_48077_scihor_24_6__2021_107_116
crossref_primary_10_1515_hmbci_2021_0058
Cites_doi 10.1016/S0140-6736(14)60460-8
10.1007/s10815-011-9544-6
10.1016/S0140-6736(11)60814-3
10.1371/journal.pone.0071459
10.1152/ajpendo.00013.2015
10.2164/jandrol.05124
10.1093/humrep/dem035
10.1016/j.yhbeh.2010.06.018
10.1096/fj.12-224048
10.14814/phy2.12336
10.1186/1742-4755-8-24
10.1093/humupd/dmp047
10.1177/1933719112440747
10.1210/jc.2007-1972
10.1016/j.fertnstert.2010.11.044
10.1073/pnas.1305609111
10.1093/humrep/dem139
10.4103/1008-682X.122203
10.1016/j.fertnstert.2012.04.004
10.1016/j.ejca.2013.11.035
10.1111/ele.12373
10.1016/j.fertnstert.2004.03.056
10.1093/humrep/des415
10.1016/j.mce.2014.09.027
10.1016/j.cell.2010.12.008
10.1016/j.urology.2015.02.001
10.1371/journal.pone.0100832
10.1093/humrep/des030
10.1016/j.cell.2014.11.005
10.1111/j.1439-0272.2009.01032.x
10.1016/j.fertnstert.2012.07.1102
10.1016/j.nut.2005.09.006
10.1038/ijo.2011.150
10.1111/j.1365-2605.2012.01265.x
10.1093/humrep/det428
10.1097/01.ede.0000229953.76862.e5
10.1093/humrep/dep465
10.1111/jsm.12828
10.1038/sj.ejhg.5201832
10.1038/nature09491
10.1111/j.1464-410X.2011.10813.x
10.1136/bmjopen-2012-000990
10.1016/j.rbmo.2011.10.014
10.1530/EJE-12-0890
10.1159/000350313
10.1530/EJE-12-0955
10.1093/molehr/gav010
10.1093/humrep/den321
10.1210/jc.2015-1571
ContentType Journal Article
Copyright Hellenic Endocrine Society 2015
Copyright_xml – notice: Hellenic Endocrine Society 2015
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.14310/horm.2002.1621
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Anatomy & Physiology
EISSN 2520-8721
EndPage 568
ExternalDocumentID 10_14310_horm_2002_1621
26732149
Genre Journal Article
Review
GrantInformation_xml – fundername: Medical Research Council
  grantid: G1002033
– fundername: Medical Research Council
  grantid: MR/K500938/1
GroupedDBID ---
-EM
406
53G
AAAVM
AAFGU
AAHNG
AAIAL
AATNV
AAUYE
AAYFA
ABDZT
ABECU
ABFGW
ABFTV
ABJNI
ABKAS
ABKCH
ABMQK
ABQBU
ABTEG
ABTKH
ABTMW
ABXPI
ACBMV
ACBRV
ACBYP
ACGFS
ACHSB
ACIGE
ACIPQ
ACMLO
ACOKC
ACTTH
ACVWB
ACWMK
ADBBV
ADKNI
ADMDM
ADOXG
ADRFC
ADTPH
ADURQ
ADYFF
AEFTE
AEJRE
AEOHA
AESKC
AESTI
AEVTX
AFNRJ
AFQWF
AGDGC
AGGBP
AGJBK
AGMZJ
AIAKS
AILAN
AIMYW
AITGF
AJDOV
AJZVZ
AKQUC
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMXSW
AMYLF
AMYQR
AXYYD
BAWUL
BGNMA
CSCUP
DIK
DPUIP
EBLON
EBS
EJD
F5P
FINBP
FNLPD
FRP
FSGXE
GGCAI
IKXTQ
IWAJR
J-C
JZLTJ
LLZTM
M4Y
NPVJJ
NQJWS
NU0
O9J
OK1
PT4
RLLFE
RSV
SISQX
SNE
SNPRN
SOHCF
SOJ
SPISZ
SRMVM
SSLCW
STPWE
SV3
TR2
TSG
UOJIU
UTJUX
UZXMN
VFIZW
ZMTXR
0R~
AACDK
AAJBT
AASML
ABAKF
ACAOD
ACDTI
ACZOJ
AEFQL
AEMSY
AFBBN
AGQEE
AGRTI
AIGIU
CGR
CUY
CVF
ECM
EIF
FIGPU
HG6
NPM
ROL
SJYHP
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c379t-629ce9079edfe928c30eead44b3463390f645d91ff6084fe63017e2c580934d03
ISSN 1109-3099
IngestDate Fri Aug 16 22:36:15 EDT 2024
Thu Sep 12 19:33:37 EDT 2024
Sat Sep 28 08:29:47 EDT 2024
Sat Dec 16 12:04:05 EST 2023
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Fertility
Sperm
Infertility
Paternal
Metabolic syndrome
Hypogonadism
Overweight
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c379t-629ce9079edfe928c30eead44b3463390f645d91ff6084fe63017e2c580934d03
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
OpenAccessLink https://www.research.ed.ac.uk/files/24630618/07_DOI_939_Chambers_HR.pdf
PMID 26732149
PQID 1764698273
PQPubID 23479
PageCount 6
ParticipantIDs proquest_miscellaneous_1764698273
crossref_primary_10_14310_horm_2002_1621
pubmed_primary_26732149
springer_journals_10_14310_horm_2002_1621
PublicationCentury 2000
PublicationDate 2015-10-01
PublicationDateYYYYMMDD 2015-10-01
PublicationDate_xml – month: 10
  year: 2015
  text: 2015-10-01
  day: 01
PublicationDecade 2010
PublicationPlace Cham
PublicationPlace_xml – name: Cham
– name: Switzerland
PublicationSubtitle International Journal of Endocrinology and Metabolism
PublicationTitle Hormones (Athens, Greece)
PublicationTitleAbbrev Hormones
PublicationTitleAlternate Hormones (Athens)
PublicationYear 2015
Publisher Springer International Publishing
Publisher_xml – name: Springer International Publishing
References Binder, Sheedy, Hannan, Gardner (CR45) 2015; 21
Fullston, Palmer, Owens, Mitchell, Bakos, Lane (CR34) 2012; 27
Le Cornet, Lortet-Tieulent, Forman (CR15) 2014; 50
Carone, Fauquier, Habib (CR41) 2010; 143
Rolland, Moal, Wagner, Royère, Mouzon (CR16) 2012; 28
Wu, Tajar, Pye, Silman (CR6) 2008; 93
Rastrelli, Carter, Ahern (CR11) 2015; 100
Aitken, Smith, Jobling, Baker, De Iuliis (CR32) 2014; 16
Kort, Massey, Eisner (CR28) 2006; 27
McPherson, Bakos, Owens, Setchell, Lane (CR50) 2013; 8
Camacho, Huhtaniemi, O’Neill (CR10) 2013; 168
Jensen, Andersson, Jørgensen (CR22) 2004; 82
Zini, Jamal, Cowan, Al-Hathal (CR31) 2011; 28
Crean, Kopps, Bonduriansky (CR47) 2014; 17
Priskorn, Holmboe, Jacobsen, Jensen, Lassen, Skakkebaek (CR14) 2012; 35
Kaati, Bygren, Pembrey, Sjöström (CR39) 2007; 15
Moragianni, Jones, Ryley (CR25) 2012; 98
McPherson, Owens, Fullston, Lane (CR51) 2015; 308
Ng, Lin, Laybutt, Barres, Owens, Morris (CR43) 2010; 467
CR3
Romero-Otero, Medina-Polo, García-Gómez (CR17) 2015; 85
Nguyen, Wilcox, Skjaerven, Baird (CR20) 2007; 22
CR49
Sermondade, Massin, Boitrelle (CR23) 2012; 24
Barratt, Aitken, Björndahl (CR29) 2010; 25
Martin, Hamilton, Osterman, Curtin, Matthews (CR13) 2015; 64
Reis, Zani, Saad, Chaim, de Oliveira, Fregonesi (CR52) 2012; 19
Fullston, Teague, Palmer (CR42) 2013; 27
Håkonsen, Thulstrup, Aggerholm (CR54) 2011; 8
Colaci, Afeiche, Gaskins (CR24) 2012; 98
Tunc, Bakos, Tremellen (CR33) 2011; 43
Fullston, McPherson, Owens, Kang, Sandeman, Lane (CR35) 2015; 3
Anderson, Riffle, Wilson, Travlos, Lubomirski, Alvord (CR40) 2006; 22
Roa, Tena-Sempere (CR9) 2014; 397
CR53
Kaya, Sikka, Gur (CR5) 2015; 12
Lane, McPherson, Fullston (CR36) 2014; 9
Ost, Lempradl, Casas (CR44) 2014; 159
MacDonald, Herbison, Showeil, Farquhar (CR7) 2010; 16
Fariello, Pariz, Spaine, Cedenho, Bertolla, Fraietta (CR27) 2012; 110
Zini, Boman, Belzile, Ciampi (CR30) 2008; 23
Bakos, Henshaw, Mitchell, Lane (CR26) 2011; 95
Corona, Rastrelli, Monami (CR12) 2013; 168
Bromfield, Schjenken, Chin, Care, Jasper, Robertson (CR46) 2014; 111
Wang, McPherson, Marsh, Gortmaker, Brown (CR2) 2011; 378
Jääskeläinen, Pussinen, Nuutinen (CR37) 2011; 35
Eisenberg, Kim, Chen, Sundaram, Schisterman, Buck Louis (CR4) 2014; 29
Curley, Mashoodh, Champagne (CR48) 2011; 59
Ramlau-Hansen, Thulstrup, Nohr, Bonde, Sørensen, Olsen (CR19) 2007; 22
Vermeulen, Kaufman, Deslypere, Thomas (CR8) 1993; 76
Sallmén, Sandler, Hoppin, Blair, Baird (CR21) 2006; 17
Ng, Fleming, Robinson (CR1) 2014; 384
Patro, Liber, Zalewski, Poston, Szajewska, Koletzko (CR38) 2013; 63
Jørgensen, Joensen, Jensen (CR18) 2012; 2
References_xml – volume: 384
  start-page: 766
  year: 2014
  end-page: 781
  ident: CR1
  article-title: Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013
  publication-title: Lancet
  doi: 10.1016/S0140-6736(14)60460-8
  contributor:
    fullname: Robinson
– volume: 28
  start-page: 391
  year: 2011
  end-page: 397
  ident: CR31
  article-title: Is sperm DNA damage associated with IVF embryo quality? A systematic review
  publication-title: J Assist Reprod Genet
  doi: 10.1007/s10815-011-9544-6
  contributor:
    fullname: Al-Hathal
– volume: 378
  start-page: 815
  year: 2011
  end-page: 825
  ident: CR2
  article-title: Health and economic burden of the projected obesity trends in the USA and the UK
  publication-title: Lancet
  doi: 10.1016/S0140-6736(11)60814-3
  contributor:
    fullname: Brown
– ident: CR49
– volume: 8
  start-page: e71459
  year: 2013
  ident: CR50
  article-title: Improving Metabolic Health in Obese Male Mice via Diet and Exercise Restores Embryo Development and Fetal Growth
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0071459
  contributor:
    fullname: Lane
– volume: 308
  start-page: E805
  year: 2015
  end-page: 821
  ident: CR51
  article-title: Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring
  publication-title: Am J Physiol — Endocrinol Metab
  doi: 10.1152/ajpendo.00013.2015
  contributor:
    fullname: Lane
– volume: 27
  start-page: 450
  year: 2006
  end-page: 452
  ident: CR28
  article-title: Impact of Body Mass Index Values on Sperm Quantity and Quality
  publication-title: J Androl
  doi: 10.2164/jandrol.05124
  contributor:
    fullname: Eisner
– volume: 22
  start-page: 1634
  year: 2007
  end-page: 1637
  ident: CR19
  article-title: Subfecundity in overweight and obese couples
  publication-title: Hum Reprod
  doi: 10.1093/humrep/dem035
  contributor:
    fullname: Olsen
– volume: 59
  start-page: 306
  year: 2011
  end-page: 314
  ident: CR48
  article-title: Epigenetics and the origins of paternal effects
  publication-title: Horm Behav
  doi: 10.1016/j.yhbeh.2010.06.018
  contributor:
    fullname: Champagne
– volume: 27
  start-page: 4226
  year: 2013
  end-page: 4243
  ident: CR42
  article-title: Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content
  publication-title: FASEB J
  doi: 10.1096/fj.12-224048
  contributor:
    fullname: Palmer
– volume: 3
  start-page: e12336
  year: 2015
  ident: CR35
  article-title: Paternal obesity induces metabolic and sperm disturbances in male offspring that are exacerbated by their exposure to an “obesogenic” diet
  publication-title: Physiol Rep
  doi: 10.14814/phy2.12336
  contributor:
    fullname: Lane
– volume: 8
  start-page: 24
  year: 2011
  ident: CR54
  article-title: Does weight loss improve semen quality and reproductive hormones? Results from a cohort of severely obese men
  publication-title: Reprod Health
  doi: 10.1186/1742-4755-8-24
  contributor:
    fullname: Aggerholm
– volume: 16
  start-page: 293
  year: 2010
  end-page: 311
  ident: CR7
  article-title: The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis
  publication-title: Hum Reprod Update
  doi: 10.1093/humupd/dmp047
  contributor:
    fullname: Farquhar
– volume: 76
  start-page: 1140
  year: 1993
  end-page: 1146
  ident: CR8
  article-title: Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men
  publication-title: J Clin Endocrinol Metab
  contributor:
    fullname: Thomas
– volume: 19
  start-page: 1057
  year: 2012
  end-page: 1062
  ident: CR52
  article-title: Bariatric Surgery Does not Interfere With Sperm Quality—A Preliminary Long-Term Study
  publication-title: Reprod Sci Thousand Oaks Calif
  doi: 10.1177/1933719112440747
  contributor:
    fullname: Fregonesi
– volume: 93
  start-page: 2737
  year: 2008
  end-page: 2745
  ident: CR6
  article-title: Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2007-1972
  contributor:
    fullname: Silman
– volume: 95
  start-page: 1700
  year: 2011
  end-page: 1704
  ident: CR26
  article-title: Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology
  publication-title: Fertil Steril
  doi: 10.1016/j.fertnstert.2010.11.044
  contributor:
    fullname: Lane
– volume: 111
  start-page: 2200
  year: 2014
  end-page: 2205
  ident: CR46
  article-title: Maternal tract factors contribute to paternal seminal fluid impact on metabolic phenotype in offspring
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1305609111
  contributor:
    fullname: Robertson
– volume: 22
  start-page: 2488
  year: 2007
  end-page: 2493
  ident: CR20
  article-title: Men’s body mass index and infertility
  publication-title: Hum Reprod Oxf Engl
  doi: 10.1093/humrep/dem139
  contributor:
    fullname: Baird
– volume: 16
  start-page: 31
  year: 2014
  end-page: 38
  ident: CR32
  article-title: Oxidative stress and male reproductive health
  publication-title: Asian J Androl
  doi: 10.4103/1008-682X.122203
  contributor:
    fullname: De Iuliis
– volume: 98
  start-page: 102
  year: 2012
  end-page: 108
  ident: CR25
  article-title: The effect of body mass index on the outcomes of first assisted reproductive technology cycles
  publication-title: Fertil Steril
  doi: 10.1016/j.fertnstert.2012.04.004
  contributor:
    fullname: Ryley
– volume: 50
  start-page: 831
  year: 2014
  end-page: 839
  ident: CR15
  article-title: Testicular cancer incidence to rise by 25% by 2025 in Europe? Model-based predictions in 40 countries using population-based registry data
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2013.11.035
  contributor:
    fullname: Forman
– volume: 17
  start-page: 1545
  year: 2014
  end-page: 1552
  ident: CR47
  article-title: Revisiting telegony: offspring inherit an acquired characteristic of their mother’s previous mate
  publication-title: Ecol Lett
  doi: 10.1111/ele.12373
  contributor:
    fullname: Bonduriansky
– volume: 82
  start-page: 863
  year: 2004
  end-page: 870
  ident: CR22
  article-title: Body mass index in relation to semen quality and reproductive hormonesamong 1,558 Danish men
  publication-title: Fertil Steril
  doi: 10.1016/j.fertnstert.2004.03.056
  contributor:
    fullname: Jørgensen
– volume: 64
  start-page: 1
  year: 2015
  end-page: 65
  ident: CR13
  article-title: Births: final data for 2013
  publication-title: Natl Vital Stat Rep Cent Dis Control Prev Natl Cent Health Stat Natl Vital Stat Syst
  contributor:
    fullname: Matthews
– volume: 28
  start-page: 462
  year: 2012
  end-page: 470
  ident: CR16
  article-title: Decline in semen concentration and morphology in a sample of 26 609 men close to general population between 1989 and 2005 in France
  publication-title: Hum Reprod
  doi: 10.1093/humrep/des415
  contributor:
    fullname: Mouzon
– volume: 397
  start-page: 4
  year: 2014
  end-page: 14
  ident: CR9
  article-title: Connecting metabolism and reproduction: roles of central energy sensors and key molecular mediators
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2014.09.027
  contributor:
    fullname: Tena-Sempere
– volume: 143
  start-page: 1084
  year: 2010
  end-page: 1096
  ident: CR41
  article-title: Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals
  publication-title: Cell
  doi: 10.1016/j.cell.2010.12.008
  contributor:
    fullname: Habib
– volume: 85
  start-page: 1333
  year: 2015
  end-page: 1338
  ident: CR17
  article-title: Semen Quality Assessment in Fertile Men in Madrid During the Last 3 Decades
  publication-title: Urology
  doi: 10.1016/j.urology.2015.02.001
  contributor:
    fullname: García-Gómez
– volume: 9
  start-page: e100832
  year: 2014
  ident: CR36
  article-title: Oxidative stress in mouse sperm impairs embryo development, fetal growth and alters adiposity and glucose regulation in female offspring
  publication-title: PloS One
  doi: 10.1371/journal.pone.0100832
  contributor:
    fullname: Fullston
– volume: 27
  start-page: 1391
  year: 2012
  end-page: 1400
  ident: CR34
  article-title: Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice
  publication-title: Hum Reprod
  doi: 10.1093/humrep/des030
  contributor:
    fullname: Lane
– volume: 159
  start-page: 1352
  year: 2014
  end-page: 1364
  ident: CR44
  article-title: Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity
  publication-title: Cell
  doi: 10.1016/j.cell.2014.11.005
  contributor:
    fullname: Casas
– volume: 43
  start-page: 121
  year: 2011
  end-page: 128
  ident: CR33
  article-title: Impact of body mass index on seminal oxidative stress
  publication-title: Andrologia
  doi: 10.1111/j.1439-0272.2009.01032.x
  contributor:
    fullname: Tremellen
– volume: 98
  start-page: 1193
  year: 2012
  end-page: 9.e1
  ident: CR24
  article-title: Men’s body mass index in relation to embryo quality and clinical outcomes in couples undergoing in vitro fertilization
  publication-title: Fertil Steril
  doi: 10.1016/j.fertnstert.2012.07.1102
  contributor:
    fullname: Gaskins
– ident: CR53
– volume: 22
  start-page: 327
  year: 2006
  end-page: 331
  ident: CR40
  article-title: Preconceptional fasting of fathers alters serum glucose in offspring of mice
  publication-title: Nutrition
  doi: 10.1016/j.nut.2005.09.006
  contributor:
    fullname: Alvord
– volume: 35
  start-page: 1289
  year: 2011
  end-page: 1294
  ident: CR37
  article-title: Intergenerational transmission of overweight among Finnish adolescents and their parents: a 16-year follow-up study
  publication-title: Int J Obes
  doi: 10.1038/ijo.2011.150
  contributor:
    fullname: Nuutinen
– volume: 35
  start-page: 449
  year: 2012
  end-page: 455
  ident: CR14
  article-title: Increasing trends in childlessness in recent birth cohorts — a registry-based study of the total Danish male population born from 1945 to 1980
  publication-title: Int J Androl
  doi: 10.1111/j.1365-2605.2012.01265.x
  contributor:
    fullname: Skakkebaek
– volume: 29
  start-page: 193
  year: 2014
  end-page: 200
  ident: CR4
  article-title: The relationship between male BMI and waist circumference on semen quality: data from the LIFE study
  publication-title: Hum Reprod Oxf Engl
  doi: 10.1093/humrep/det428
  contributor:
    fullname: Buck Louis
– volume: 17
  start-page: 520
  year: 2006
  end-page: 523
  ident: CR21
  article-title: Reduced fertility among overweight and obese men
  publication-title: Epidemiol Camb Mass
  doi: 10.1097/01.ede.0000229953.76862.e5
  contributor:
    fullname: Baird
– volume: 25
  start-page: 824
  year: 2010
  end-page: 838
  ident: CR29
  article-title: Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications—a position report
  publication-title: Hum Reprod Oxf Engl
  doi: 10.1093/humrep/dep465
  contributor:
    fullname: Björndahl
– volume: 12
  start-page: 856
  year: 2015
  end-page: 875
  ident: CR5
  article-title: A Comprehensive Review of Metabolic Syndrome Affecting Erectile Dysfunction
  publication-title: J Sex Med
  doi: 10.1111/jsm.12828
  contributor:
    fullname: Gur
– volume: 15
  start-page: 784
  year: 2007
  end-page: 790
  ident: CR39
  article-title: Transgenerational response to nutrition, early life circumstances and longevity
  publication-title: Eur J Hum Genet
  doi: 10.1038/sj.ejhg.5201832
  contributor:
    fullname: Sjöström
– volume: 467
  start-page: 963
  year: 2010
  end-page: 966
  ident: CR43
  article-title: Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
  publication-title: Nature
  doi: 10.1038/nature09491
  contributor:
    fullname: Morris
– volume: 110
  start-page: 863
  year: 2012
  end-page: 867
  ident: CR27
  article-title: Association between obesity and alteration of sperm DNA integrity and mitochondrial activity
  publication-title: BJU Int
  doi: 10.1111/j.1464-410X.2011.10813.x
  contributor:
    fullname: Fraietta
– volume: 2
  start-page: e000990
  year: 2012
  ident: CR18
  article-title: Human semen quality in the new millennium: a prospective cross-sectional population-based study of 4867 men
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2012-000990
  contributor:
    fullname: Jensen
– volume: 24
  start-page: 206
  year: 2012
  end-page: 210
  ident: CR23
  article-title: Sperm parameters and male fertility after bariatric surgery: three case series
  publication-title: Reprod Biomed Online
  doi: 10.1016/j.rbmo.2011.10.014
  contributor:
    fullname: Boitrelle
– ident: CR3
– volume: 168
  start-page: 445
  year: 2013
  end-page: 455
  ident: CR10
  article-title: Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study
  publication-title: Eur J Endocrinol Eur Fed Endocr Soc
  doi: 10.1530/EJE-12-0890
  contributor:
    fullname: O’Neill
– volume: 63
  start-page: 32
  year: 2013
  end-page: 41
  ident: CR38
  article-title: Maternal and Paternal Body Mass Index and Offspring Obesity: A Systematic Review
  publication-title: Ann Nutr Metab
  doi: 10.1159/000350313
  contributor:
    fullname: Koletzko
– volume: 168
  start-page: 829
  year: 2013
  end-page: 843
  ident: CR12
  article-title: Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis
  publication-title: Eur J Endocrinol Eur Fed Endocr Soc
  doi: 10.1530/EJE-12-0955
  contributor:
    fullname: Monami
– volume: 21
  start-page: 424
  year: 2015
  end-page: 434
  ident: CR45
  article-title: Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model
  publication-title: Mol Hum Reprod
  doi: 10.1093/molehr/gav010
  contributor:
    fullname: Gardner
– volume: 23
  start-page: 2663
  year: 2008
  end-page: 2668
  ident: CR30
  article-title: Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis
  publication-title: Hum Reprod Oxf Engl
  doi: 10.1093/humrep/den321
  contributor:
    fullname: Ciampi
– volume: 100
  start-page: 3172
  year: 2015
  end-page: 3182
  ident: CR11
  article-title: Development of and Recovery from Secondary Hypogonadism in Ageing Men: Prospective Results from the EMAS
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2015-1571
  contributor:
    fullname: Ahern
SSID ssj0065981
Score 2.332955
SecondaryResourceType review_article
Snippet Obesity in men of reproductive age is globally on the increase. There is clear evidence from epidemiological studies that obesity impacts negatively on male...
SourceID proquest
crossref
pubmed
springer
SourceType Aggregation Database
Index Database
Publisher
StartPage 563
SubjectTerms Animals
DNA Damage
Endocrinology
Female
Fertility
Humans
Hypogonadism - etiology
Hypogonadism - pathology
Hypogonadism - physiopathology
Hypogonadism - prevention & control
Infertility, Male - etiology
Infertility, Male - pathology
Infertility, Male - physiopathology
Infertility, Male - prevention & control
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Obesity - complications
Obesity - pathology
Obesity - physiopathology
Obesity - therapy
Pregnancy
Prognosis
Review
Risk Assessment
Risk Factors
Spermatogenesis
Spermatozoa - pathology
Weight Loss
Title The impact of obesity on male fertility
URI https://link.springer.com/article/10.14310/horm.2002.1621
https://www.ncbi.nlm.nih.gov/pubmed/26732149
https://search.proquest.com/docview/1764698273
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELZakKpeUAt9bB_Ilao-tErIw89jQNAVEpxA4hYltiMubCp2ObS_vjOON8kWkIBLtGuNHGVmMvlmPA9CvuoKviE2t5GulI1YxZOokjW4KsxaljJjjO_deXIqZufs-IJfDOOOfHXJso7N3zvrSp4iVVgDuWKV7CMk228KC_Ab5AtXkDBcHyzjocyx7Xr8Y_j_Csz-tMGUaUTZYwA6A4yK7fkRWRbY-WARKlWccaOowMFlhZNCRjlE0-N4-iseogbWQ_VRbf60iMchhJT3yWjrIcT_gpBDHGxkH1OfKtHNNIqdX8s4eKBKdoXOvVFlI-VhIwvJgz1z4Z-6044DrMHMx0vgiU8jiVMR9l9vjo0uDNKWSIkjNbMSKZ-TzUxqDs74ZnG0v3-6-jYLrv3Y2v4xQrMn3GJv_WbrOOWW83Hr4NzjkbNXZCs4ErTotOI1eebm22SnAL62V3_oN-pTe_2ZyTZ5cRIyKHbId9AZ2ukMbRsadIa2c4o6Q3udeUPOjw7PDmZRGJYRmVzqZSQybZxOpHa2cTpTJk8cWAnG6pyJPNdJIxi3Om0akSjWOAGWXbrMcJXonNkkf0s25qB_7wlVtXKWVeAraIHDyZUw0iQOfG2gB0A5IT9WrCl_dz1RynsEMSFfVqwrwW7hYVQ1d-3NokylwOGlgJ4n5F3H036zTEicn6Un5OeKyWV47Rb33enDI2g_kpfDa_CJbCyvb9xnwJbLejcozD_I8HNc
link.rule.ids 315,786,790,27957,27958
linkProvider Library Specific Holdings
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+impact+of+obesity+on+male+fertility&rft.jtitle=Hormones+%28Athens%2C+Greece%29&rft.au=Chambers%2C+Thomas+J.+G.&rft.au=Anderson%2C+Richard+A.&rft.date=2015-10-01&rft.pub=Springer+International+Publishing&rft.issn=1109-3099&rft.eissn=2520-8721&rft.volume=14&rft.issue=4&rft.spage=563&rft.epage=568&rft_id=info:doi/10.14310%2Fhorm.2002.1621&rft.externalDocID=10_14310_horm_2002_1621
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1109-3099&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1109-3099&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1109-3099&client=summon