The impact of obesity on male fertility

Obesity in men of reproductive age is globally on the increase. There is clear evidence from epidemiological studies that obesity impacts negatively on male fertility; it is associated with hypogonadism, although it is less consistently linked to impaired spermatogenesis and tests of sperm function,...

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Bibliographic Details
Published inHormones (Athens, Greece) Vol. 14; no. 4; pp. 563 - 568
Main Authors Chambers, Thomas J. G., Anderson, Richard A.
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.10.2015
Subjects
Animals
DNA Damage
Endocrinology
Female
Fertility
Humans
Hypogonadism - etiology
Hypogonadism - pathology
Hypogonadism - physiopathology
Hypogonadism - prevention & control
Infertility, Male - etiology
Infertility, Male - pathology
Infertility, Male - physiopathology
Infertility, Male - prevention & control
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Obesity - complications
Obesity - pathology
Obesity - physiopathology
Obesity - therapy
Pregnancy
Prognosis
Review
Risk Assessment
Risk Factors
Spermatogenesis
Spermatozoa - pathology
Weight Loss
Fertility
Sperm
Infertility
Paternal
Metabolic syndrome
Hypogonadism
Overweight
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Summary:Obesity in men of reproductive age is globally on the increase. There is clear evidence from epidemiological studies that obesity impacts negatively on male fertility; it is associated with hypogonadism, although it is less consistently linked to impaired spermatogenesis and tests of sperm function, including DNA fragmentation. Sperm from obese men used for in vitro fertilisation/intra cytoplasmic sperm injection is associated with a greater number of pregnancy losses and is less likely to result in live births. There are also increasing data from animal studies that paternal obesity may impact negatively on the reproductive and metabolic health of offspring and grand-offspring. It has been suggested that high-fat dietary exposures could affect the epigenetic content of sperm or the endocrine content of seminal fluid and thus impact early fetal development. Experimental and epidemiological data show that male fertility, and offspring health, can be improved by weight loss in obese and overweight males.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1109-3099
2520-8721
DOI:10.14310/horm.2002.1621