The Cosmetic Ingredient Review Program-Expert Safety Assessments of Cosmetic Ingredients in an Open Forum

• Published in: International journal of toxicology Vol. 36; no. 5_suppl2; p. 5S
• Main Authors: Boyer, Ivan J, Bergfeld, Wilma F, Heldreth, Bart, Fiume, Monice M, Gill, Lillian J
• Format: Journal Article
• Language: English
• Published: United States 01.09.2017
• Subjects: Animals; Consumer Product Safety; Cosmetics - chemistry; Cosmetics - toxicity; Humans; Organizations, Nonprofit; United States; United States Food and Drug Administration; safety assessment; expert panel; hydrolyzed wheat protein; formaldehyde; read across; botanical
• ISSN: 1092-874X
• DOI: 10.1177/1091581817717646

The Cosmetic Ingredient Review (CIR) is a nonprofit program to assess the safety of ingredients in personal care products in an open, unbiased, and expert manner. Cosmetic Ingredient Review was established in 1976 by the Personal Care Products Council (PCPC), with the support of the US Food and Drug Administration (USFDA) and the Consumer Federation of America (CFA). Cosmetic Ingredient Review remains the only scientific program in the world committed to the systematic, independent review of cosmetic ingredient safety in a public forum. Cosmetic Ingredient Review operates in accordance with procedures modeled after the USFDA process for reviewing over-the-counter drugs. Nine voting panel members are distinguished, such as medical professionals, scientists, and professors. Three nonvoting liaisons are designated by the USFDA, CFA, and PCPC to represent government, consumer, and industry, respectively. The annual rate of completing safety assessments accelerated from about 100 to more than 400 ingredients by implementing grouping and read-across strategies and other approaches. As of March 2017, CIR had reviewed 4,740 individual cosmetic ingredients, including 4,611 determined to be safe as used or safe with qualifications, 12 determined to be unsafe, and 117 ingredients for which the information is insufficient to determine safety. Examples of especially challenging safety assessments and issues are presented here, including botanicals. Cosmetic Ingredient Review continues to strengthen its program with the ongoing cooperation of the USFDA, CFA, the cosmetics industry, and everyone else interested in contributing to the process.