Diffuse Leptomeningeal Oligodendrogliomatosis in a Cow

A 4.5-year-old cow showing neurological signs consistent with predictors of bovine spongiform encephalopathy (BSE) was investigated as a potential BSE-suspect case and proved to be negative. Macroscopic analysis revealed a tan neoplastic mass growing along the leptomeninges of the caudal brain and e...

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Bibliographic Details
Published inVeterinary pathology Vol. 57; no. 2; pp. 253 - 257
Main Authors Kauer, Ronja V., Bagatella, Stefano, Oevermann, Anna
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.03.2020
Subjects
Animals
Biomarkers - metabolism
Cattle
Cattle Diseases - diagnosis
Cattle Diseases - pathology
Diagnosis, Differential
Encephalopathy, Bovine Spongiform - diagnosis
Encephalopathy, Bovine Spongiform - pathology
Female
Immunohistochemistry - veterinary
Meningeal Neoplasms - diagnosis
Meningeal Neoplasms - pathology
Meningeal Neoplasms - veterinary
Oligodendrocyte Transcription Factor 2 - metabolism
Oligodendroglioma - diagnosis
Oligodendroglioma - pathology
Oligodendroglioma - veterinary
diffuse leptomeningeal glioneuronal tumor
oligodendroglioma
BSE
bovine
cattle
Olig2
disseminated oligodendroglioma-like neoplasm
leptomeningeal growth
neuropathology
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Summary:A 4.5-year-old cow showing neurological signs consistent with predictors of bovine spongiform encephalopathy (BSE) was investigated as a potential BSE-suspect case and proved to be negative. Macroscopic analysis revealed a tan neoplastic mass growing along the leptomeninges of the caudal brain and extending into the third (III) ventricle without significantly involving the neuroparenchyma. Pathological features (uniform round hyperchromatic neoplastic cells embedded in abundant myxoid matrix, microcysts, microvascular proliferation) and diffuse Olig2 expression were most consistent with diffuse high-grade leptomeningeal oligodendrogliomatosis. In line with former reports of extensive leptomeningeal involvement in bovine oligodendroglioma, this report suggests that bovine oligodendroglial tumors have a strong propensity to grow within the leptomeningeal space. In addition, it indicates that Olig2 is a useful marker to confirm glial lineage in formalin-fixed, paraffin-embedded bovine tissue.
Bibliography:ObjectType-Case Study-2
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ISSN:0300-9858
1544-2217
DOI:10.1177/0300985819887534