Dextran Sulfate Sodium (DSS)-Induced Acute Colitis in the Rat

Inflammatory bowel diseases (IBDs) are complex multifactorial disease thought to result from inappropriate immune responses to the gut microbiota, in genetically susceptible individuals, under the influence of environmental factors. Among the different animal models developed to help in understandin...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 1371; p. 197
Main Authors Martin, Jérôme C, Bériou, Gaëlle, Josien, Régis
Format Journal Article
LanguageEnglish
Published United States 2016
Subjects
Animals
Colitis - chemically induced
Colitis - pathology
Dextran Sulfate - administration & dosage
Dextran Sulfate - adverse effects
Disease Models, Animal
Rats
Rats, Sprague-Dawley
Inflammatory bowel disease
Animal models
Dextran sodium sulfate
Rats
Colitis
Crohn’s disease
Ulcerative colitis
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Summary:Inflammatory bowel diseases (IBDs) are complex multifactorial disease thought to result from inappropriate immune responses to the gut microbiota, in genetically susceptible individuals, under the influence of environmental factors. Among the different animal models developed to help in understanding IBDs pathophysiological mechanisms as well as to achieve pharmacological preclinical studies, the dextran sulfate sodium (DSS)-induced colitis model is the most widely used because of its simplicity, cost-effectiveness, and similarity with human IBDs. This section provides with a detailed protocol that we validated in our laboratory to perform DSS-induced acute colitis in the Sprague-Dawley (SPD) rat.
ISSN:1940-6029
DOI:10.1007/978-1-4939-3139-2_12