Effects of saikosaponins on liver tyrosine aminotransferase activity induced by cortisone in adrenalectomized rats

• Published in: Planta medica Vol. 51; no. 5; pp. 401 - 403
• Main Authors: Hashimoto, M, Inada, K, Ohminami, H, Kimura, Y, Okuda, H, Arichi, S
• Format: Journal Article
• Language: English
• Published: Germany 01.10.1985
• Subjects: bupleum falcatum; cortisone; enzyme activity; liver; rats; roots; saponins; tyrosine transaminase
• ISSN: 0032-0943; 1439-0221
• DOI: 10.1055/s-2007-969531

Liver tyrosine aminotransferase activity is known to be induced by administration of steroids to adrenalectomized rats. When saikosaponin a, b (1), b (2), b (3), b (4), c, d or f was injected intraperitoneally into adrenalectomized rats, no induction of liver tyrosine aminotransferase activity was observed. Administration of a low dose of cortisone (6.4 micromol/kg) to adrenalectomized rats also did not induce liver tyrosine aminotransferase. But this enzyme was induced on administration of this low dose of cortisone with saikosaponen a (6.4 or 12.8 micromol/kg), d (6.4 or 12.8 micromol/kg) or f (12.8 micromol/kg). The sturcture-activity relationship of the effects of various Saikosaponins on the action of cortisone is discuused.