Drug Survival, Effectiveness and Safety of Secukinumab in Axial Spondyloarthritis up to 4 Years: A Real-Life Single Center Experience

• Published in: Journal of personalized medicine Vol. 14; no. 4; p. 417
• Main Authors: Diaconu, Alexandra-Diana, Pomîrleanu, Cristina, Russu, Mara, Strugariu, Georgiana, Ancuța, Eugen, Ciortescu, Irina, Bologa, Cristina, Morărașu, Bianca Codrina, Constantin, Mihai, Ceasovschih, Alexandr, Șorodoc, Victorița, Șorodoc, Laurențiu, Ancuța, Codrina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2024
• Subjects: Adalimumab; Ankylosing spondylitis; Anti-inflammatory agents; Arthritis; Biological products; Blood; C-reactive protein; Comparative analysis; Cytokines; Erythrocyte sedimentation rate; Immunotherapy; Inflammation; Inflammatory bowel disease; Inflammatory diseases; Kinases; Medical examination; Medical prognosis; Nonsteroidal anti-inflammatory drugs; Patient outcomes; Patients; Porter, Bo; Psoriasis; Remission (Medicine); Rheumatic diseases; Rheumatology; Sacroiliitis; Safety; Statistical analysis; Survival; TNF inhibitors; Toxicity; Tumor necrosis factor-TNF; Romania; biologic-experienced patients; biologic-naïve; secukinumab; dropout rate; axial spondyloarthritis; drug survival; retention rate
• ISSN: 2075-4426; 2075-4426
• DOI: 10.3390/jpm14040417

(1) Objective: The main aims of our study were to explore the drug survival and effectiveness of secukinumab in patients with axial spondyloarthritis (axSpA). (2) Methods: We underwent a retrospective analysis of consecutive axSpA treated with secukinumab as a first line of biologics or at switch in a biologic-experienced population. Efficacy data, indicating improvement in inflammation parameters (such as C-reactive protein and erythrocyte sedimentation rate) and disease activity scores (such as Ankylosing Spondylitis Disease Activity Score [ASDAS-CRP], Bath Ankylosing Spondylitis Disease Activity Index [BASDAI]), and patient-reported outcomes (pain), were assessed at 6, 12, 24, 36 and 48 months. The drug survival rate, dropout rate and discontinuation reasons (efficacy versus safety) of secukinumab were assessed in subgroup analysis (axSpA with and without exposure to biologics). (3) Results: In total, 46 patients were exposed to the IL-17A inhibitor secukinumab. The drug survival for axSpA patients 59.7% at 12 months and 31.3% at 24 months. There were no statistically significant differences in the median drug survival between biologic-naïve versus biologic-experienced subgroups. (4) Conclusions: Secukinumab has demonstrated effectiveness and safety in treating a cohort of axSpA patients in real-world settings, with a notable retention rate of the drug.