Research advances on the usage of traditional Chinese medicine for neuroprotection in glaucoma

Progressive loss of retinal ganglion cells （RGCs） and their axons is the main pathogenesis of glaucoma. The cause of glaucoma is not fully understood, but the neurodegeneration of glaucoma involves many mechanisms such as oxidative stress, glutamate toxicity and ischemia/ reperfusion insult. In orde...

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Bibliographic Details
Published inJournal of integrative medicine Vol. 11; no. 4; pp. 233 - 240
Main Authors Mi, Xue-song, Zhong, Jing-xiang, Chang, Raymond Chuen-Chung, So, Kwok-Fai
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2013
Subjects
Clinical Trials as Topic
Drugs, Chinese Herbal - therapeutic use
Ginkgo biloba
glaucoma
Glaucoma - drug therapy
Humans
Medicine, Chinese Traditional
neuroprotection
neuroprotective agents
Neuroprotective Agents - therapeutic use
Retinal Ganglion Cells - pathology
review
traditional Chinese medicine
中国传统医学
再灌注
发病机制
用法
神经保护作用
神经退行性疾病
缺血
视网膜神经节细胞
青光眼
traditional Chinese medicine
neuroprotective agents
neuroprotection
glaucoma
review
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Summary:Progressive loss of retinal ganglion cells （RGCs） and their axons is the main pathogenesis of glaucoma. The cause of glaucoma is not fully understood, but the neurodegeneration of glaucoma involves many mechanisms such as oxidative stress, glutamate toxicity and ischemia/ reperfusion insult. In order to target these mechanisms, multiple neuroprotective interventions have been investigated to prevent the death of RGCs. Of note are some tonic herbs from the traditional Chinese medicine （TCM） pharmacopeia that have shown neuroprotective effects in glaucoma. TCM differs from Western medicine in that TCM exhibits complicated bioactive com- ponents, triggering many signaling pathways and extensive actions on vital organs. Modern scientific approaches have demonstrated some of their underlying mechanisms. In this review, we used Lycium barbarum and Ginkgo biloba as examples to elaborate the characteristics of TCM and their potential applications in neuroprotection in glaucoma.
Bibliography:neuroprotection; neuroprotective agents; traditional Chinese medicine; glaucoma;review
31-2083/R
Progressive loss of retinal ganglion cells （RGCs） and their axons is the main pathogenesis of glaucoma. The cause of glaucoma is not fully understood, but the neurodegeneration of glaucoma involves many mechanisms such as oxidative stress, glutamate toxicity and ischemia/ reperfusion insult. In order to target these mechanisms, multiple neuroprotective interventions have been investigated to prevent the death of RGCs. Of note are some tonic herbs from the traditional Chinese medicine （TCM） pharmacopeia that have shown neuroprotective effects in glaucoma. TCM differs from Western medicine in that TCM exhibits complicated bioactive com- ponents, triggering many signaling pathways and extensive actions on vital organs. Modern scientific approaches have demonstrated some of their underlying mechanisms. In this review, we used Lycium barbarum and Ginkgo biloba as examples to elaborate the characteristics of TCM and their potential applications in neuroprotection in glaucoma.
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ISSN:2095-4964
DOI:10.3736/jintegrmed2013037