The kinetic characteristics of inhibition of hepatic cholesterogenesis by lipoproteins of intestinal origin
In these studies intestinal lipoproteins were injected intravenously into recipient rats in order to study the kinetic characteristics of cholesterol uptake by the liver cell and inhibition of the cholesterol synthetic pathway. Net cholesterol uptake from circulating intestinal lipoproteins took pla...
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Published in | The Journal of biological chemistry Vol. 250; no. 11; pp. 4145 - 4151 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Biochemistry and Molecular Biology
10.06.1975
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Subjects | |
Online Access | Get full text |
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Summary: | In these studies intestinal lipoproteins were injected intravenously into recipient rats in order to study the kinetic characteristics
of cholesterol uptake by the liver cell and inhibition of the cholesterol synthetic pathway. Net cholesterol uptake from circulating
intestinal lipoproteins took place only in the liver, and only this tissue manifested inhibition of cholesterol syntheses.
Cholesterol uptake by the liver, quantified by a rise in the cholesterol ester content, was a linear function of time and
of the amount of lipoprotein cholesterol administered to the animals. Using groups of rats that were either fed cholesterol
or injected intravenously with intestinal lipoproteins as a bolus or as a continuous infusion, there was generally a correlation
between inhibition of the rate of cholesterol synthesis and the cholesterol ester content of the liver. However, there was
no consistent quantitative relationship between these two variables suggesting either that cholesterol ester was not the immediate
effector of the inhibition or, alternatively, that there was intracellular localization of the effector at the site of control
of the rate-limiting enzyme in the cholesterogenic pathway. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0021-9258 1083-351X |
DOI: | 10.1016/S0021-9258(19)41398-7 |