Use of intravenous polymyxin B during continuous venovenous hemodialysis

• Published in: European journal of clinical microbiology & infectious diseases Vol. 23; no. 4; pp. 340 - 341
• Main Authors: SARRIA, J. C, ANGULO-PERNETT, F, KIMBROUGH, R. C, MCVAY, C. S, VIDAL, A. M
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.04.2004; Springer Nature B.V
• Subjects: Acinetobacter baumannii - isolation & purification; Acinetobacter Infections - diagnosis; Acinetobacter Infections - drug therapy; Acute Kidney Injury - etiology; Acute Kidney Injury - therapy; Adult; Bacteremia - diagnosis; Bacteremia - drug therapy; Biological and medical sciences; Dialysis; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Hemodialysis; Humans; Infectious diseases; Infusions, Intravenous; Male; Medical sciences; Microbiology; Multiple Trauma - complications; Multiple Trauma - diagnosis; Multiple Trauma - therapy; Polymyxin B - administration & dosage; Renal Dialysis - adverse effects; Renal Dialysis - methods; Risk Assessment; Treatment Outcome; Infection; Extrarenal dialysis; Antibiotic; Intravenous administration; Microbiology; Hemodialysis; Cyclic peptides; Polypeptide; Use; Antibacterial agent; Polymyxin B
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-004-1106-8

Described here is the case of a 23-year-old male with Acinetobacter baumannii sepsis and acute renal failure requiring continuous venovenous hemodialysis treated successfully with intravenous polymyxin B. The drug was administered as a loading dose of 2.5 mg/kg, followed by 2 doses of 1 mg/kg on days 4 and 8, then 0.8 mg/kg daily to complete a 24-day course. A discussion of dosing recommendations for polymyxins in dialysis is presented.