Neutrophil migration induced by inflammatory stimuli is reduced by macrophage depletion

Previous experiments of our group have shown that neutrophil migration induced by inflammatory stimuli is reduced by agents which block the release from macrophages of a specific factor for neutrophil migration (MNCF, [1, 2]). The present paper evaluated the influence of macrophage depletion induced...

Full description

Saved in:
Bibliographic Details
Published inAgents and actions Vol. 24; no. 3-4; p. 377
Main Authors Souza, G E, Cunha, F Q, Mello, R, Ferreira, S H
Format Journal Article
LanguageEnglish
Published Switzerland 01.07.1988
Subjects
Animals
Carrageenan
Chemotactic Factors - pharmacology
Endotoxins
Escherichia coli
Inflammation - immunology
Leukocyte Migration-Inhibitory Factors
Lymphokines
Macrophages - physiology
Male
Neutrophils - cytology
Neutrophils - drug effects
Rats
Rats, Inbred Strains
Zymosan
Online AccessGet more information

Cover

More Information
Summary:Previous experiments of our group have shown that neutrophil migration induced by inflammatory stimuli is reduced by agents which block the release from macrophages of a specific factor for neutrophil migration (MNCF, [1, 2]). The present paper evaluated the influence of macrophage depletion induced by lavage of the peritoneal cavity on neutrophil migration. In both normal and thioglycollate-stimulated peritoneal cavities, lavage with saline reduced the resident macrophage population by about 80% and significantly blocked neutrophil migration induced by inflammatory stimuli such as carrageenin, zymosan and E. coli endotoxin. Peritoneal lavage, however, did not affect neutrophil migration induced by MNCF. Thus, these results support the suggestion that macrophages participate in the control of neutrophil migration induced by acute inflammatory stimuli.
ISSN:0065-4299
DOI:10.1007/bf02028296