Cefodizime in skin suction blister fluid and serum following a single intravenous or intramuscular dose in adult patients

Cefodizime is a third generation cephalosporin for parenteral use. The pharmacokinetics of this cephem antibiotic were determined in serum and skin suction blister fluid (SBF) after intravenous (i.v.) or intramuscular (i.m.) administration of a single 1 g dose in 8 adult patients with normal renal a...

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Published inJournal of chemotherapy (Florence) Vol. 12; no. 4; p. 306
Main Authors Mazzei, T, Novelli, A, Esposito, S, Fallani, S, Noviello, S, Cassetta, M I, Conti, S, Periti, P
Format Journal Article
LanguageEnglish
Published England 01.08.2000
Subjects
Adult
Blister - metabolism
Body Fluids - metabolism
Cefotaxime - analogs & derivatives
Cefotaxime - blood
Cefotaxime - pharmacokinetics
Cephalosporins - blood
Cephalosporins - pharmacokinetics
Humans
Infusions, Intravenous
Injections, Intramuscular
Kidney Function Tests
Liver Function Tests
Male
Respiratory Tract Diseases - blood
Respiratory Tract Diseases - metabolism
Skin - metabolism
Suction
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Summary:Cefodizime is a third generation cephalosporin for parenteral use. The pharmacokinetics of this cephem antibiotic were determined in serum and skin suction blister fluid (SBF) after intravenous (i.v.) or intramuscular (i.m.) administration of a single 1 g dose in 8 adult patients with normal renal and hepatic function who volunteered for the study. The concentration versus time curve showed a slower elimination rate from the extravascular compartment: the half-lives were 4.4+/-0.5 and 5.4+/-0.4 hours after i.v. and i.m. route respectively. The relatively long elimination half-life in SBF with a mean residence time of about 8 hours allows the use of cefodizime once-a-day for the treatment of infections due to sensitive pathogens.
ISSN:1120-009X
DOI:10.1179/joc.2000.12.4.306