Poly(Lactic Acid)-co-Aspartic Acid Copolymers: Possible Utilization in Drug Delivery Systems
The synthesis and characterization of poly(lactic acid)-co-aspartic acid copolymers (PLA-co-Asp) were presented. Subsequently, the synthesized PLA-co-Asp copolymers were tested as biodegradable carriers in drug delivery systems. PLA-co-Asp copolymers were synthesized by solution polycondensation pro...
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| Published in | Journal of polymers and the environment Vol. 21; no. 4; pp. 1064 - 1071 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Springer US
01.12.2013
Springer Springer Nature B.V |
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| Abstract | The synthesis and characterization of poly(lactic acid)-co-aspartic acid copolymers (PLA-co-Asp) were presented. Subsequently, the synthesized PLA-co-Asp copolymers were tested as biodegradable carriers in drug delivery systems. PLA-co-Asp copolymers were synthesized by solution polycondensation procedure, using different molar ratios PLA/
l
-aspartic acid (2.33/1, 1/1, 1/2.33), manganese acetate and phosphoric acid as catalysts and
N
,
N
′-dimethyl formamide (DMF)/toluene as solvent mixture. The copolymers were characterized by FT-IR and
1
H-NMR spectroscopy, gel permeation chromatography (GPC), DSC and TG-DTG analyses. Diclofenac sodium, a non steroidal anti-inflammatory drug was subsequently loaded into PLA-co-Asp copolymers. The in vitro drug release experiments were done by dialysis of the copolymer/drug systems, in phosphate buffer solution (pH = 7.4, at 37 °C) and monitored by UV spectroscopy. |
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| AbstractList | The synthesis and characterization of poly(lactic acid)-co-aspartic acid copolymers (PLA-co-Asp) were presented. Subsequently, the synthesized PLA-co-Asp copolymers were tested as biodegradable carriers in drug delivery systems. PLA-co-Asp copolymers were synthesized by solution polycondensation procedure, using different molar ratios PLA/
l
-aspartic acid (2.33/1, 1/1, 1/2.33), manganese acetate and phosphoric acid as catalysts and
N
,
N
′-dimethyl formamide (DMF)/toluene as solvent mixture. The copolymers were characterized by FT-IR and
1
H-NMR spectroscopy, gel permeation chromatography (GPC), DSC and TG-DTG analyses. Diclofenac sodium, a non steroidal anti-inflammatory drug was subsequently loaded into PLA-co-Asp copolymers. The in vitro drug release experiments were done by dialysis of the copolymer/drug systems, in phosphate buffer solution (pH = 7.4, at 37 °C) and monitored by UV spectroscopy. The synthesis and characterization of poly(lactic acid)-co-aspartic acid copolymers (PLA-co-Asp) were presented. Subsequently, the synthesized PLA-co-Asp copolymers were tested as biodegradable carriers in drug delivery systems. PLA-co-Asp copolymers were synthesized by solution polycondensation procedure, using different molar ratios PLA/l-aspartic acid (2.33/1, 1/1, 1/2.33), manganese acetate and phosphoric acid as catalysts and N,N'-dimethyl formamide (DMF)/toluene as solvent mixture. The copolymers were characterized by FT-IR and ^sup 1^H-NMR spectroscopy, gel permeation chromatography (GPC), DSC and TG-DTG analyses. Diclofenac sodium, a non steroidal anti-inflammatory drug was subsequently loaded into PLA-co-Asp copolymers. The in vitro drug release experiments were done by dialysis of the copolymer/drug systems, in phosphate buffer solution (pH = 7.4, at 37 °C) and monitored by UV spectroscopy.[PUBLICATION ABSTRACT] The synthesis and characterization of poly(lactic acid)-co-aspartic acid copolymers (PLA-co-Asp) were presented. Subsequently, the synthesized PLA-co-Asp copolymers were tested as biodegradable carriers in drug delivery systems. PLA-co-Asp copolymers were synthesized by solution polycondensation procedure, using different molar ratios PLA/l-aspartic acid (2.33/1, 1/1, 1/2.33), manganese acetate and phosphoric acid as catalysts and N,N'-dimethyl formamide (DMF)/toluene as solvent mixture. The copolymers were characterized by FT-IR and super(1)H-NMR spectroscopy, gel permeation chromatography (GPC), DSC and TG-DTG analyses. Diclofenac sodium, a non steroidal anti-inflammatory drug was subsequently loaded into PLA-co-Asp copolymers. The in vitro drug release experiments were done by dialysis of the copolymer/drug systems, in phosphate buffer solution (pH = 7.4, at 37 degree C) and monitored by UV spectroscopy. |
| Author | Vasile, Cornelia Mustata, Fanica Tudorachi, Nita Lipsa, Rodica |
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| CitedBy_id | crossref_primary_10_1021_acsbiomaterials_1c00150 crossref_primary_10_3390_ma13163615 crossref_primary_10_1016_j_jconrel_2017_11_009 crossref_primary_10_1016_j_tca_2015_05_018 crossref_primary_10_5301_jabfm_5000289 crossref_primary_10_1002_app_52907 crossref_primary_10_3390_polym13172953 crossref_primary_10_1002_pat_5031 crossref_primary_10_1007_s10311_024_01729_z crossref_primary_10_3390_pharmaceutics14020359 |
| Cites_doi | 10.1016/S0168-3659(00)00342-4 10.1038/201068a0 10.1023/A:1020200822435 10.1007/s11458-009-0092-x 10.14314/polimery.2006.425 10.1002/mabi.200390007 10.1002/masy.200851210 10.3349/ymj.2000.41.6.720 10.1016/0032-3861(96)00267-4 10.1016/0378-5173(92)90134-N 10.1007/s10924-011-0317-1 10.1016/S0032-3861(96)01079-8 10.1007/s10924-012-0470-1 10.1208/s12249-008-9126-9 10.1021/bm1006773 |
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| Keywords | Diclofenac sodium Drug delivery systems Poly(lactic acid)-co-aspartic acid Biodegradable copolymers Solution polycondensation Molecular structure Control release polymer Lactic acid copolymer Drug carrier Experimental study In vitro Diclofenac Non steroidal antiinflammatory agent Monodispersed polymer Cyclopolymer Preparation Diblock copolymer Microparticle Aspartic acid Imide copolymer Kinetics Release Aliphatic copolymer Amphiphilic polymer |
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| SubjectTerms | Acetates Acids Anti-inflammatory agents Applied sciences Biodegradation Biological and medical sciences Chemistry Chemistry and Materials Science Copolymers Dialysis Diclofenac Drug delivery systems Drugs Environmental Chemistry Environmental Engineering/Biotechnology Exact sciences and technology General pharmacology Industrial Chemistry/Chemical Engineering Manganese Materials Science Medical sciences Organic polymers Original Paper Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phosphates Physicochemistry of polymers Polymer Sciences Polymers with particular properties Preparation, kinetics, thermodynamics, mechanism and catalysts Sodium Spectroscopy Toluene Ultraviolet spectroscopy |
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| Title | Poly(Lactic Acid)-co-Aspartic Acid Copolymers: Possible Utilization in Drug Delivery Systems |
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