Poly(Lactic Acid)-co-Aspartic Acid Copolymers: Possible Utilization in Drug Delivery Systems

• Published in: Journal of polymers and the environment Vol. 21; no. 4; pp. 1064 - 1071
• Main Authors: Tudorachi, Nita, Lipsa, Rodica, Vasile, Cornelia, Mustata, Fanica
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.12.2013; Springer; Springer Nature B.V
• Subjects: Acetates; Acids; Anti-inflammatory agents; Applied sciences; Biodegradation; Biological and medical sciences; Chemistry; Chemistry and Materials Science; Copolymers; Dialysis; Diclofenac; Drug delivery systems; Drugs; Environmental Chemistry; Environmental Engineering/Biotechnology; Exact sciences and technology; General pharmacology; Industrial Chemistry/Chemical Engineering; Manganese; Materials Science; Medical sciences; Organic polymers; Original Paper; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Phosphates; Physicochemistry of polymers; Polymer Sciences; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; Sodium; Spectroscopy; Toluene; Ultraviolet spectroscopy; Diclofenac sodium; Drug delivery systems; Poly(lactic acid)-co-aspartic acid; Biodegradable copolymers; Solution polycondensation; Molecular structure; Control release polymer; Lactic acid copolymer; Drug carrier; Experimental study; In vitro; Diclofenac; Non steroidal antiinflammatory agent; Monodispersed polymer; Cyclopolymer; Preparation; Diblock copolymer; Microparticle; Aspartic acid; Imide copolymer; Kinetics; Release; Aliphatic copolymer; Amphiphilic polymer
• ISSN: 1566-2543; 1572-8919; 1572-8900
• DOI: 10.1007/s10924-013-0587-x

The synthesis and characterization of poly(lactic acid)-co-aspartic acid copolymers (PLA-co-Asp) were presented. Subsequently, the synthesized PLA-co-Asp copolymers were tested as biodegradable carriers in drug delivery systems. PLA-co-Asp copolymers were synthesized by solution polycondensation procedure, using different molar ratios PLA/ l -aspartic acid (2.33/1, 1/1, 1/2.33), manganese acetate and phosphoric acid as catalysts and N , N ′-dimethyl formamide (DMF)/toluene as solvent mixture. The copolymers were characterized by FT-IR and 1 H-NMR spectroscopy, gel permeation chromatography (GPC), DSC and TG-DTG analyses. Diclofenac sodium, a non steroidal anti-inflammatory drug was subsequently loaded into PLA-co-Asp copolymers. The in vitro drug release experiments were done by dialysis of the copolymer/drug systems, in phosphate buffer solution (pH = 7.4, at 37 °C) and monitored by UV spectroscopy.