Adenosine Triphosphate in Liver after Partial Hepatectomy and Acute Stress
Partial hepatectomy and acute stress (Celite) cause no changes in the levels in vivo of liver ATP or total adenine nucleotide in the nucleus or the whole cell of the rat. During a brief period of anoxia (about ½ min), however, both regenerating and stressed livers destroy more of their ATP than the...
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Published in | The Journal of biological chemistry Vol. 242; no. 21; pp. 4963 - 4971 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Biochemistry and Molecular Biology
10.11.1967
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Subjects | |
Online Access | Get full text |
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Summary: | Partial hepatectomy and acute stress (Celite) cause no changes in the levels in vivo of liver ATP or total adenine nucleotide in the nucleus or the whole cell of the rat. During a brief period of anoxia (about
½ min), however, both regenerating and stressed livers destroy more of their ATP than the normal organ, and the change is
reflected in the nuclei as well as in the whole cells. That the greater ATP breakdown already occurs before oxygen is withheld
is strongly suggested by the enhanced rate of incorporation of 32 P-labeled orthophosphate into the liver ATP of the treated rats.
The kinetics of the changes in ATP metabolism is different in partially hepatectomized and stressed rats, and only the changes
in the stressed animals are dependent upon the adrenal glands.
The possibility is considered that the stimuli for the altered metabolism of ATP are causally related to the changes in the
synthesis of macromolecules that characteristically follow partial hepatectomy and acute stress. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0021-9258 1083-351X |
DOI: | 10.1016/S0021-9258(18)99463-9 |