An Efficient and General Method for the Synthesis of α,ω-Difunctional Reduced Polypropionates by Zr-Catalyzed Asymmetric Carboalumination: Synthesis of the Scyphostatin Side Chain
A decrease in the number of linear synthetic steps and an increase in efficiency have been realized in the synthesis of the side chain of scyphostatin. An efficient and selective synthesis of α,ω‐difunctional reduced polypropionates from methyl 3‐hydroxy‐2‐methylpropionate through the use of a Zr‐ca...
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Published in | Angewandte Chemie (International ed.) Vol. 43; no. 22; pp. 2911 - 2914 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
24.05.2004
WILEY‐VCH Verlag Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | A decrease in the number of linear synthetic steps and an increase in efficiency have been realized in the synthesis of the side chain of scyphostatin. An efficient and selective synthesis of α,ω‐difunctional reduced polypropionates from methyl 3‐hydroxy‐2‐methylpropionate through the use of a Zr‐catalyzed asymmetric carboalumination has been developed (see scheme, TBS=tert‐butyldimethylsilyl). |
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Bibliography: | ark:/67375/WNG-BS2ZVPHK-H ArticleID:ANIE200353429 istex:BB00914B4242B7B50633E112D24DB6786A8140CF We thank the National Institutes of Heath (grant no. GM36792) and Purdue University for their support of this research, and Boulder Scientific Co. for assistance in the procurement of Zr compounds. The collaborative efforts of B. Liang, T. Novak, and M. Magnin-Lachaux are acknowledged. We thank the National Institutes of Heath (grant no. GM36792) and Purdue University for their support of this research, and Boulder Scientific Co. for assistance in the procurement of Zr compounds. The collaborative efforts of B. Liang, T. Novak, and M. Magnin‐Lachaux are acknowledged. Medline ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.200353429 |