TRP64ARG polymorphism of the β3-adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle

• Published in: Diabetes, obesity & metabolism Vol. 4; no. 6; pp. 428 - 430
• Main Authors: Marti, A., Corbalán, M. S., Martínez-Gonzalez, M. A., Martinez, J. A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.11.2002
• Subjects: case-control study; obesity; recreational energy expenditure; Trp64Arg mutation; β3-adrenergic receptor
• ISSN: 1462-8902; 1463-1326
• DOI: 10.1046/j.1463-1326.2002.00227.x

Aim: We performed a case–control study to assess the association between obesity risk and the Trp64Arg polymorphism of the β3‐adrenergic receptor gene. Methods: Obese subjects [n = 159; body mass index (BMI) > 30 kg/m2] and controls (n = 154; BMI < 25 kg/m2) were compared using multivariable logistic regression to control for potential confounders. Results: A higher obesity risk (adjusted OR: 2.98; 95% CI: 1.00–8.56; p = 0.05) was associated with the Trp64Arg polymorphism among sedentary, but not among more active people. Conclusions: Our results suggest that the TRP64ARG polymorphism of the ADRB3 seems to be a risk factor for obesity that is dependent on a sedentary lifestyle.