Self-Assembling Peptide Polyelectrolyte β-Sheet Complexes Form Nematic Hydrogels

Fibrillar networks built up from polyelectrolyte β‐sheet complexes (see picture) are formed by spontaneous self‐assembly when solutions of appropriately designed cationic and anionic oligopeptides are mixed. At the macroscopic level the resulting solutions are nematic hydrogels, which are quite robu...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 42; no. 45; pp. 5603 - 5606
Main Authors Aggeli, Amalia, Bell, Mark, Boden, Neville, Carrick, Lisa M., Strong, Andrew E.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 24.11.2003
WILEY‐VCH Verlag
Subjects
Electrolytes - chemistry
gels
Hydrogels - chemistry
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
peptides
Peptides - chemistry
phase transitions
Protein Structure, Secondary
self-assembly
Spectroscopy, Fourier Transform Infrared
β-sheets
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Summary:Fibrillar networks built up from polyelectrolyte β‐sheet complexes (see picture) are formed by spontaneous self‐assembly when solutions of appropriately designed cationic and anionic oligopeptides are mixed. At the macroscopic level the resulting solutions are nematic hydrogels, which are quite robust to variations in pH or peptide concentration.
Bibliography:istex:4A2DBEB357DA66760BCD83C71E468463454B3EF1
The work was supported by the UK Engineering and Physical Sciences Research Council and the Royal Society (University research fellowship to A.A.).
ArticleID:ANIE200352207
ark:/67375/WNG-641BTJJJ-V
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200352207