Microplate evaluation of process adsorbents

• Published in: Journal of separation science Vol. 25; no. 13; pp. 847 - 850
• Main Authors: Welch, Christopher J., Shaimi, Mohamed, Biba, Mirlinda, Chilenski, Jennifer R., Szumigala Jr, Ronald H., Dolling, Ulf, Mathre, David J., Reider, Paul J.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.09.2002; WILEY‐VCH Verlag; Wiley
• Subjects: Analytical chemistry; Batch adsorption; Chemistry; Chromatographic methods and physical methods associated with chromatography; Exact sciences and technology; High-Throughput screening; LC-MS; Other chromatographic methods; Process adsorbents; Evaluation; Solid phase extraction; Purification; Impurity; Microtiter plate; Zinc II Ions; Coupled method; HPLC chromatography; Colorimetry; Selectivity; Binding capacity; Sample preparation; Adsorbent; Mass spectrometry; Flow injection

A microplate‐based assay to rapidly identify adsorbents suitable for removing process impurities is described. A solution containing both product and impurity is added to a number of wells, each containing a small amount of a candidate adsorbent. After equilibration, analysis of the supernatant solu...