Microplate evaluation of process adsorbents

• Published in: Journal of separation science Vol. 25; no. 13; pp. 847 - 850
• Main Authors: Welch, Christopher J., Shaimi, Mohamed, Biba, Mirlinda, Chilenski, Jennifer R., Szumigala Jr, Ronald H., Dolling, Ulf, Mathre, David J., Reider, Paul J.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.09.2002; WILEY‐VCH Verlag; Wiley
• Subjects: Analytical chemistry; Batch adsorption; Chemistry; Chromatographic methods and physical methods associated with chromatography; Exact sciences and technology; High-Throughput screening; LC-MS; Other chromatographic methods; Process adsorbents; Evaluation; Solid phase extraction; Purification; Impurity; Microtiter plate; Zinc II Ions; Coupled method; HPLC chromatography; Colorimetry; Selectivity; Binding capacity; Sample preparation; Adsorbent; Mass spectrometry; Flow injection
• ISSN: 1615-9306; 1615-9314
• DOI: 10.1002/1615-9314(20020901)25:13<847::AID-JSSC847>3.0.CO;2-2

A microplate‐based assay to rapidly identify adsorbents suitable for removing process impurities is described. A solution containing both product and impurity is added to a number of wells, each containing a small amount of a candidate adsorbent. After equilibration, analysis of the supernatant solution allows one to determine the extent of adsorption of both product and impurity. Fast analysis techniques such as flow injection analysis LC‐MS or the use of colorimetric indicators allows rapid identification of the most selective adsorbents for a given separation problem.